3qkd
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of Bcl-xL in complex with a Quinazoline sulfonamide inhibitor== | ==Crystal structure of Bcl-xL in complex with a Quinazoline sulfonamide inhibitor== | ||
<StructureSection load='3qkd' size='340' side='right' caption='[[3qkd]], [[Resolution|resolution]] 2.02Å' scene=''> | <StructureSection load='3qkd' size='340' side='right' caption='[[3qkd]], [[Resolution|resolution]] 2.02Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3qkd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3qkd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QKD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QKD FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HI0:(R)-N-(7-(4-((4-CHLOROBIPHENYL-2-YL)METHYL)PIPERAZIN-1-YL)QUINAZOLIN-4-YL)-4-(4-(DIMETHYLAMINO)-1-(PHENYLTHIO)BUTAN-2-YLAMINO)-3-NITROBENZENESULFONAMIDE'>HI0</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HI0:(R)-N-(7-(4-((4-CHLOROBIPHENYL-2-YL)METHYL)PIPERAZIN-1-YL)QUINAZOLIN-4-YL)-4-(4-(DIMETHYLAMINO)-1-(PHENYLTHIO)BUTAN-2-YLAMINO)-3-NITROBENZENESULFONAMIDE'>HI0</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL2L1, BCL2L, BCLX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qkd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qkd RCSB], [http://www.ebi.ac.uk/pdbsum/3qkd PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qkd OCA], [http://pdbe.org/3qkd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qkd RCSB], [http://www.ebi.ac.uk/pdbsum/3qkd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qkd ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| Line 17: | Line 18: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3qkd" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| Line 24: | Line 26: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Czabotar, P E]] | [[Category: Czabotar, P E]] | ||
[[Category: Smith, B J]] | [[Category: Smith, B J]] | ||
[[Category: Apoptosis-inhibitor complex]] | [[Category: Apoptosis-inhibitor complex]] | ||
[[Category: Bcl-2 family fold]] | [[Category: Bcl-2 family fold]] | ||
Revision as of 16:28, 5 August 2016
Crystal structure of Bcl-xL in complex with a Quinazoline sulfonamide inhibitor
| |||||||||||
