2f87

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|PDB= 2f87 |SIZE=350|CAPTION= <scene name='initialview01'>2f87</scene>
|PDB= 2f87 |SIZE=350|CAPTION= <scene name='initialview01'>2f87</scene>
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f87 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f87 OCA], [http://www.ebi.ac.uk/pdbsum/2f87 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f87 RCSB]</span>
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[[Category: srp]]
[[Category: srp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:49:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:14 2008''

Revision as of 23:59, 30 March 2008

Image:2f87.gif


PDB ID 2f87

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Ligands: , , ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Solution structure of a GAAG tetraloop in SRP RNA from Pyrococcus furiosus


Overview

The NMR structure of a 12-mer RNA derived from the helix 6 of SRP RNA from Pyrococcus furiosus, whose loop-closing base pair is U.G, was determined, and the structural and thermodynamic properties of the RNA were compared with those of a mutant RNA with the C:G closing base pair. Although the structures of the two RNAs are similar to each other and adopt the GNRR motif the conformational stabilities are significantly different to each other It was suggested that weaker stacking interaction of the GAAG loop with the U:G closing base pair in 12-mer RNA causes the lower conformational stability.

About this Structure

2F87 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Solution structure of a GAAG tetraloop in helix 6 of SRP RNA from Pyrococcus furiosus., Okada K, Takahashi M, Sakamoto T, Kawai G, Nakamura K, Kanai A, Nucleosides Nucleotides Nucleic Acids. 2006;25(4-6):383-95. PMID:16838833

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