2f8i
From Proteopedia
(Difference between revisions)
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|PDB= 2f8i |SIZE=350|CAPTION= <scene name='initialview01'>2f8i</scene>, resolution 1.541Å | |PDB= 2f8i |SIZE=350|CAPTION= <scene name='initialview01'>2f8i</scene>, resolution 1.541Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=205:2-(2,6-DICHLOROPHENYL)-1,3-BENZOXAZOLE-6-CARBOXYLIC ACID'>205</scene> | + | |LIGAND= <scene name='pdbligand=205:2-(2,6-DICHLOROPHENYL)-1,3-BENZOXAZOLE-6-CARBOXYLIC+ACID'>205</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= TTR, PALB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= TTR, PALB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8i OCA], [http://www.ebi.ac.uk/pdbsum/2f8i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f8i RCSB]</span> | ||
}} | }} | ||
'''Human transthyretin (TTR) complexed with Benzoxazole''' | '''Human transthyretin (TTR) complexed with Benzoxazole''' | ||
| - | |||
| - | ==Disease== | ||
| - | Known diseases associated with this structure: Amyloid neuropathy, familial, several allelic types OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176300 176300]], Amyloidosis, senile systemic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176300 176300]], Carpal tunnel syndrome, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176300 176300]], Dystransthyretinemic hyperthyroxinemia OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=176300 176300]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Palaninathan, S K.]] | [[Category: Palaninathan, S K.]] | ||
[[Category: Sacchettini, J C]] | [[Category: Sacchettini, J C]] | ||
| - | [[Category: | + | [[Category: amyloid]] |
| - | [[Category: | + | [[Category: transthyretin]] |
| + | [[Category: ttr]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:59:23 2008'' |
Revision as of 23:59, 30 March 2008
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| , resolution 1.541Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | TTR, PALB (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Human transthyretin (TTR) complexed with Benzoxazole
About this Structure
2F8I is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action., Razavi H, Palaninathan SK, Powers ET, Wiseman RL, Purkey HE, Mohamedmohaideen NN, Deechongkit S, Chiang KP, Dendle MT, Sacchettini JC, Kelly JW, Angew Chem Int Ed Engl. 2003 Jun 23;42(24):2758-61. PMID:12820260
Page seeded by OCA on Mon Mar 31 02:59:23 2008
