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2zjk
From Proteopedia
(Difference between revisions)
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==Crystal structure of the human BACE1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid(3-mercapto-propyl)-amide== | ==Crystal structure of the human BACE1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid(3-mercapto-propyl)-amide== | ||
<StructureSection load='2zjk' size='340' side='right' caption='[[2zjk]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='2zjk' size='340' side='right' caption='[[2zjk]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2zjk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2zjk]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZJK FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F1K:(2S)-4-(4-FLUOROBENZYL)-N-(3-SULFANYLPROPYL)PIPERAZINE-2-CARBOXAMIDE'>F1K</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F1K:(2S)-4-(4-FLUOROBENZYL)-N-(3-SULFANYLPROPYL)PIPERAZINE-2-CARBOXAMIDE'>F1K</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zjh|2zjh]], [[2zji|2zji]], [[2zjj|2zjj]], [[2zjl|2zjl]], [[2zjm|2zjm]], [[2zjn|2zjn]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zjh|2zjh]], [[2zji|2zji]], [[2zjj|2zjj]], [[2zjl|2zjl]], [[2zjm|2zjm]], [[2zjn|2zjn]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zjk RCSB], [http://www.ebi.ac.uk/pdbsum/2zjk PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zjk OCA], [http://pdbe.org/2zjk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zjk RCSB], [http://www.ebi.ac.uk/pdbsum/2zjk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zjk ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zjk ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Lam, M B]] | [[Category: Lam, M B]] | ||
Revision as of 18:45, 5 August 2016
Crystal structure of the human BACE1 catalytic domain in complex with 4-(4-fluoro-benzyl)-piperazine-2-carboxylic acid(3-mercapto-propyl)-amide
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Categories: Human | Memapsin 2 | Lam, M B | Lu, W | Randal, M | Romanowski, M J | Aspartyl protease | Bace1 | Glycoprotein | Hydrolase | Membrane | Protease | Small-molecule inhibitor | Tethering | Transmembrane | Zymogen
