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3m42

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==Crystal structure of MAPKAP kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor==
==Crystal structure of MAPKAP kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor==
<StructureSection load='3m42' size='340' side='right' caption='[[3m42]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
<StructureSection load='3m42' size='340' side='right' caption='[[3m42]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3m42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M42 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3m42]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3M42 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HGF:2-[5-(2-METHOXYETHOXY)PYRIDIN-3-YL]-8,9,10,11-TETRAHYDRO-7H-PYRIDO[3,4 4,5]PYRROLO[2,3-F]ISOQUINOLIN-7-ONE'>HGF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HGF:2-[5-(2-METHOXYETHOXY)PYRIDIN-3-YL]-8,9,10,11-TETRAHYDRO-7H-PYRIDO[3,4 4,5]PYRROLO[2,3-F]ISOQUINOLIN-7-ONE'>HGF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kga|3kga]], [[3m2w|3m2w]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kga|3kga]], [[3m2w|3m2w]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAPKAPK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAPKAPK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3m42 RCSB], [http://www.ebi.ac.uk/pdbsum/3m42 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3m42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m42 OCA], [http://pdbe.org/3m42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3m42 RCSB], [http://www.ebi.ac.uk/pdbsum/3m42 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3m42 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Be, C]]
[[Category: Be, C]]

Revision as of 19:56, 5 August 2016

Crystal structure of MAPKAP kinase 2 (MK2) complexed with a tetracyclic ATP site inhibitor

3m42, resolution 2.68Å

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