2fom
From Proteopedia
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|PDB= 2fom |SIZE=350|CAPTION= <scene name='initialview01'>2fom</scene>, resolution 1.50Å | |PDB= 2fom |SIZE=350|CAPTION= <scene name='initialview01'>2fom</scene>, resolution 1.50Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Flavivirin Flavivirin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.91 3.4.21.91] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2fom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fom OCA], [http://www.ebi.ac.uk/pdbsum/2fom PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2fom RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2FOM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | + | 2FOM is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FOM OCA]. |
==Reference== | ==Reference== | ||
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16532006 16532006] | Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16532006 16532006] | ||
| - | [[Category: Dengue virus | + | [[Category: Dengue virus 2]] |
[[Category: Flavivirin]] | [[Category: Flavivirin]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: Renatus, M.]] | [[Category: Renatus, M.]] | ||
[[Category: Schiering, N.]] | [[Category: Schiering, N.]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: GOL]] | ||
[[Category: flavivirus]] | [[Category: flavivirus]] | ||
[[Category: ns2b cofactor]] | [[Category: ns2b cofactor]] | ||
[[Category: ns3 protease]] | [[Category: ns3 protease]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:05:40 2008'' |
Revision as of 00:05, 31 March 2008
| |||||||
| , resolution 1.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Activity: | Flavivirin, with EC number 3.4.21.91 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Dengue Virus NS2B/NS3 Protease
Overview
The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.
About this Structure
2FOM is a Protein complex structure of sequences from Dengue virus 2. Full crystallographic information is available from OCA.
Reference
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus., Erbel P, Schiering N, D'Arcy A, Renatus M, Kroemer M, Lim SP, Yin Z, Keller TH, Vasudevan SG, Hommel U, Nat Struct Mol Biol. 2006 Apr;13(4):372-3. Epub 2006 Mar 12. PMID:16532006
Page seeded by OCA on Mon Mar 31 03:05:40 2008
