Antithrombin
From Proteopedia
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| - | {{ | + | {{STRUCTURE_13evj| PDB=3evj | SIZE=400| SCENE= |right|CAPTION=Antithrombin (beige) complex with thrombin heavy chain (pink), light chain (green) and heparin polysaccharide, [[1tb6]] }} |
'''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interaction of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation. See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]]. | '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interaction of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation. See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]]. | ||
| - | + | == Function == | |
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| + | '''Antithrombin''' (AT) inactivates several enzymes of the coagulation cycle. AT is relatively inactive until it binds the heparan sidechains of the microvasculature.<br /> | ||
| + | ▪ α-AT contains 4 occupied glycosylation sites and is found in blood palsma.<br /> | ||
| + | ▪ β-AT contains only 3 occupied glycosylation sites.<br /> | ||
| + | ▪ AT-I refers to the absorption of thrombin to fibrin.<br /> | ||
| + | ▪ AT-II and heparin interfere with the interaction of thrombin and fibrinogen.<br /> | ||
| + | ▪ AT-III inactivates thrombin in plasma.<br /> | ||
| + | ▪ AT-IV becomes activated during blood coagulation.<br /> | ||
| + | See details for the antithrombin pentasaccharide complex in [[Molecular Playground/Antithrombin-Heparin]]. | ||
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| + | == Disease == | ||
| + | |||
| + | AT deficiency diseases are: Acquired AT deficiency and Inherited AT deficiency. AT deficiency is involved in thrombosis and pulmonary embolism. | ||
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| + | == Relevance == | ||
| + | AT activity is enhanced upon binding to the anticoagulant drug heparin. | ||
| + | |||
| + | ==Structural highlights== | ||
| + | |||
| + | The binding of AT to the heparans or the heparin drug is to a core pentasaccharide. The binding induces conformational change of AT. | ||
==3D structures of antithrombin== | ==3D structures of antithrombin== | ||
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*Antithrombin binary complexes | *Antithrombin binary complexes | ||
| - | **[[1azx]], [[1nq9]], [[3evj]] | + | **[[1azx]], [[1nq9]], [[3evj]], [[1e03]] – hAT III + heparin pentasaccharide |
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**[[1dzh]] - hAT-III (mutant) + fluorescein | **[[1dzh]] - hAT-III (mutant) + fluorescein | ||
Revision as of 09:24, 3 November 2015
Antithrombin (AT) inactivates several enzymes of the coagulation cycle. α-AT contains 4 occupied glycosylation sites and is found in blood palsma. β-AT contains only 3 occupied glycosylation sites. AT-I refers to the absorption of thrombin to fibrin; AT-II and heparin interfere with the interaction of thrombin and fibrinogen; AT-III inactivates thrombin in plasma; AT-IV becomes activated during blood coagulation. See details for the antithrombin pentasaccharide complex in Molecular Playground/Antithrombin-Heparin.
Contents |
Function
Antithrombin (AT) inactivates several enzymes of the coagulation cycle. AT is relatively inactive until it binds the heparan sidechains of the microvasculature.
▪ α-AT contains 4 occupied glycosylation sites and is found in blood palsma.
▪ β-AT contains only 3 occupied glycosylation sites.
▪ AT-I refers to the absorption of thrombin to fibrin.
▪ AT-II and heparin interfere with the interaction of thrombin and fibrinogen.
▪ AT-III inactivates thrombin in plasma.
▪ AT-IV becomes activated during blood coagulation.
See details for the antithrombin pentasaccharide complex in Molecular Playground/Antithrombin-Heparin.
Disease
AT deficiency diseases are: Acquired AT deficiency and Inherited AT deficiency. AT deficiency is involved in thrombosis and pulmonary embolism.
Relevance
AT activity is enhanced upon binding to the anticoagulant drug heparin.
Structural highlights
The binding of AT to the heparans or the heparin drug is to a core pentasaccharide. The binding induces conformational change of AT.
3D structures of antithrombin
Updated on 03-November-2015
