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Thioesterase
From Proteopedia
(Difference between revisions)
| Line 70: | Line 70: | ||
**[[2qq2]] - hTE7 C terminal<br /> | **[[2qq2]] - hTE7 C terminal<br /> | ||
**[[3fo5]] – hTE11 START domain<br /> | **[[3fo5]] – hTE11 START domain<br /> | ||
| - | **[[3b7k]] – hTE12<br /> | + | **[[3b7k]], [[4moc]] – hTE12<br /> |
| + | **[[4mob]] – hTE12 + ADP<br /> | ||
**[[3rd7]] – TE – ''Mycobacterium avium''<br /> | **[[3rd7]] – TE – ''Mycobacterium avium''<br /> | ||
**[[3u0a]] – TEII – ''Mycobacterium marinum''<br /> | **[[3u0a]] – TEII – ''Mycobacterium marinum''<br /> | ||
| - | **[[1tbu]] – TE N terminal (peroximal) – yeast | + | **[[1tbu]] – TE N terminal (peroximal) – yeast<br /> |
| + | **[[4qfw]] – YpTE II – ''Yersinia pestis''<br /> | ||
| + | **[[4r4u]] – YpTE II + CoA<br /> | ||
*Acyl protein thioesterase | *Acyl protein thioesterase | ||
| Line 83: | Line 86: | ||
**[[2ess]] – TE – ''Bacterioides thetaiotaomicron''<br /> | **[[2ess]] – TE – ''Bacterioides thetaiotaomicron''<br /> | ||
**[[4gak]] – TE – ''Spirosoma linguale''<br /> | **[[4gak]] – TE – ''Spirosoma linguale''<br /> | ||
| - | **[[4gwh]] – | + | **[[4gwh]] – YpTE <br /> |
*ACP-polyene thioesterase | *ACP-polyene thioesterase | ||
| Line 102: | Line 105: | ||
**[[4k00]] – TE – ''Synechocystis''<br /> | **[[4k00]] – TE – ''Synechocystis''<br /> | ||
| - | **[[4k02]] – | + | **[[4k02]] – AtTE – ''Arabidopsis thaliana''<br /> |
*RedJ thioesterase | *RedJ thioesterase | ||
| Line 151: | Line 154: | ||
**[[2ylm]] – hUSP C terminal domain <br /> | **[[2ylm]] – hUSP C terminal domain <br /> | ||
**[[2f1x]], [[2f1y]], [[2foj]], [[2foo]], [[2fop]] – hUSP N terminal domain/peptide <br /> | **[[2f1x]], [[2f1y]], [[2foj]], [[2foo]], [[2fop]] – hUSP N terminal domain/peptide <br /> | ||
| + | **[[4zv3]] – mUSP N terminal domain <br /> | ||
*Ubiquitin thioesterase 7 complexes | *Ubiquitin thioesterase 7 complexes | ||
| Line 161: | Line 165: | ||
**[[4jjq]] – hUSP TRAF domain + E2 peptide<br /> | **[[4jjq]] – hUSP TRAF domain + E2 peptide<br /> | ||
**[[4kg9]] – hUSP TRAF domain + MCM-BP peptide<br /> | **[[4kg9]] – hUSP TRAF domain + MCM-BP peptide<br /> | ||
| + | **[[4yoc]] – hUSP residues 560-1102 + DNA methyl transferase<br /> | ||
*Ubiquitin thioesterase 8 | *Ubiquitin thioesterase 8 | ||
| Line 190: | Line 195: | ||
**[[2ayn]] – hUSP<br /> | **[[2ayn]] – hUSP<br /> | ||
**[[2ayo]] – hUSP + Ub aldehyde<br /> | **[[2ayo]] – hUSP + Ub aldehyde<br /> | ||
| + | **[[1wiv]] – AtUSP UBA domain - NMR<br /> | ||
*Ubiquitin thioesterase 15 | *Ubiquitin thioesterase 15 | ||
| Line 222: | Line 228: | ||
**[[3ihr]] – hUSP (mutant) <BR /> | **[[3ihr]] – hUSP (mutant) <BR /> | ||
**[[3a7s]] – hUSP catalytic domain (mutant) <BR /> | **[[3a7s]] – hUSP catalytic domain (mutant) <BR /> | ||
| + | **[[3u12]] – hUSP pleckstrin domain <br /> | ||
| + | |||
| + | *USP 38 | ||
| + | |||
| + | **[[4rxx]] – hUSP N terminal <BR /> | ||
*Ubiquitin thioesterase Cyld | *Ubiquitin thioesterase Cyld | ||
| Line 248: | Line 259: | ||
**[[3tb3]] – hUSP UCH domain (mutant) <BR /> | **[[3tb3]] – hUSP UCH domain (mutant) <BR /> | ||
**[[3ihr]] – hUSP-L5 (mutant) <br /> | **[[3ihr]] – hUSP-L5 (mutant) <br /> | ||
| + | **[[4uel]] – hUSP-L5 + polyUb + proteasomal Ub receptor Deubad domain <br /> | ||
| + | **[[4uem]] – hUSP-L5 + proteasomal Ub receptor Deubad domain <br /> | ||
| + | **[[4wlq]] – mUSP-L5 + proteasomal Ub receptor C terminal <br /> | ||
| + | **[[4wlr]] – mUSP-L5 + polyUb + proteasomal Ub receptor C terminal <br /> | ||
| + | **[[4uf5]], [[4wlp]] – hUSP-L5 + nuclear factor Deubad domain <br /> | ||
| + | **[[4uf6]] – hUSP-L5 + polyUb + nuclear factor Deubad domain <br /> | ||
*Ubiquitin thioesterase ZranB1 | *Ubiquitin thioesterase ZranB1 | ||
**[[3zrh]] – hUSP <BR /> | **[[3zrh]] – hUSP <BR /> | ||
| + | **[[4s1z]] – bUSP zinc finger + Ub <BR /> | ||
*Ubiquitin thioesterase OTUB1 | *Ubiquitin thioesterase OTUB1 | ||
| Line 258: | Line 276: | ||
**[[4ddg]], [[4ddi]] – hUSP + Ub<BR /> | **[[4ddg]], [[4ddi]] – hUSP + Ub<BR /> | ||
**[[4i6l]] – hUSP (mutant) + Ub<BR /> | **[[4i6l]] – hUSP (mutant) + Ub<BR /> | ||
| - | **[[4dhz]] – hUSP + E2 + Ub<BR /> | + | **[[4dhz]], [[4ldt]] – hUSP + E2 + Ub<BR /> |
**[[4boq]] - hUSP OTU domain <BR /> | **[[4boq]] - hUSP OTU domain <BR /> | ||
**[[4boz]] - hUSP OTU domain (mutant) + Ub <BR /> | **[[4boz]] - hUSP OTU domain (mutant) + Ub <BR /> | ||
| Line 272: | Line 290: | ||
**[[3znh]] – USP OTU domain + Ub – Crimean-Congo hemorrhagic fever virus<BR /> | **[[3znh]] – USP OTU domain + Ub – Crimean-Congo hemorrhagic fever virus<BR /> | ||
| + | |||
| + | *Pseudomonas aeruginosa TE | ||
| + | |||
| + | **[[2av9]], [[2o5u]], [[2o6b]], [[2o6t]], [[2o6u]], [[3qy3]] – PaTE – Pseudomonas aeruginosa | ||
| + | **[[4qd7]] – PaTE hotdog domain<br /> | ||
| + | **[[4qda]], [[4qdb]] – PaTE hotdog domain (mutant)<br /> | ||
| + | **[[4qd8]], [[4dq9]] – PaTE hotdog domain + acyl-CoA derivatives<br /> | ||
| + | |||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:26, 18 June 2015
Thioesterase (TE) catalyzes the break of an ester bond to produce acid and alcohol at a thiol group. TEs are substrate-specific.
- Palmitoyl protein TE removes fatty acids like palmitate from modified cysteine residues during lysosomal degradation. For details see Palmitoyl protein thioesterase.
- 4-hydroxybenzoyl-CoA TE converts 4-hydroxybenzoyl-CoA to 4-hydroxybenzoate and CoA.
- Acyl-CoA TE hydrolyzes acyl-CoA to the fatty acid and CoA and is involved in lipid metabolism.
- Fluoroacetyl-CoA TE from Streptomyces cattleya hydrolyzes fluoroacetyl-CoA thus preventing it from being metabolized to the lethal 4-hydroxy-trans-aconitate.
- Ubiquitin TE or ubiquitin carboxyl-terminal hydrolase (USP) removes conjugated ubiquitin (Ub) from proteins thus regulating protein level by preventing their degradation. USP hydrolyze the peptide bond at the C-terminal glycine of ubiquitin (UB). The USPs are involved in the processing of poly-UB precursors and of ubiquinated proteins. USP contains catalytic domain surrounded several domains: Ub-like (UBL); Ub-associated (UBA); zinc finger-Ub-specific protease domain (UBP or DUSP); TRF homology domain.
- USP-L1, USP25 hydrolyze C-terminal adducts of UB.
- USP-L3 hydrolyze C-terminal adducts of UB and NEDD8.
- USP5 cleaves multiubiquitin polymers.
- USP6 has ATP-independent isopeptidase activity.
- USP7, USP4, USP13, USP15 deubiquitinate several proteins.
- USP8 removes conjugated ubiquitin from proteins thus preventing protein degradation. USP8 is involved in cell proliferation and is active in the M phase of proliferation.
- USP11, USP14 are proteasome-associated.
- USP16, USP21 deubiquitinate histone H2A.
- USP28 deubiquitinates proteins of the DNA damage pathway.
- USP33 regulates centrosome duplication.
- USP37 deubiquitinates cyclin A.
3D structures of thioesterase
Updated on 18-June-2015
