4x9u
From Proteopedia
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| - | ''' | + | ==Crystal structure of the kiwifruit allergen Act d 5== |
| + | <StructureSection load='4x9u' size='340' side='right' caption='[[4x9u]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4x9u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinidia_deliciosa Actinidia deliciosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X9U FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PXU:2-HYDROXY-L-PROLINE'>PXU</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x9u RCSB], [http://www.ebi.ac.uk/pdbsum/4x9u PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KIWEL_ACTDE KIWEL_ACTDE]] Kissper is an anion-selective pore-forming peptide.<ref>PMID:18186145</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Kiwellin (Act d 5) is an allergenic protein contained in kiwifruit pulp in high amounts. The aim of this study was to investigate the three-dimensional structure of the natural molecule from green kiwifruit and its possible function. Kiwellin was crystallized, and its structure, including post-translational modifications, was elucidated. The molecular weight and structural features, in solution, were analyzed by gel filtration and circular dichroism, respectively. Although structurally similar to expansin, kiwellin lacks expansin activity and carbohydrate binding. A specific algorithm was applied to investigate any possible IgE reactivity correlation between kiwellin and a panel of 102 allergens, including expansins and other carbohydrate-binding allergens. The available data suggest a strong dependence of the kiwellin structure on the environmental/experimental conditions. This dependence therefore poses challenges in detecting the correlations between structural, functional, and immunological features of this protein. | ||
| - | + | Elusive Structural, Functional, and Immunological Features of Act d 5, the Green Kiwifruit Kiwellin.,Offermann LR, Giangrieco I, Perdue ML, Zuzzi S, Santoro M, Tamburrini M, Cosgrove DJ, Mari A, Ciardiello MA, Chruszcz M J Agric Food Chem. 2015 Jul 21. PMID:26146952<ref>PMID:26146952</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Actinidia deliciosa]] | ||
| + | [[Category: Chruszcz, M]] | ||
| + | [[Category: Ciardiello, M A]] | ||
| + | [[Category: Giangrieco, I]] | ||
| + | [[Category: Offermann, L R]] | ||
| + | [[Category: Perdue, M L]] | ||
[[Category: Tamburrini, M]] | [[Category: Tamburrini, M]] | ||
| - | [[Category: | + | [[Category: Allergen]] |
| - | [[Category: | + | [[Category: Plant protein]] |
| - | + | ||
| - | + | ||
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Revision as of 14:42, 29 July 2015
Crystal structure of the kiwifruit allergen Act d 5
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