4xdl

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m (Protected "4xdl" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.==
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<StructureSection load='4xdl' size='340' side='right' caption='[[4xdl]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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The entry 4xdl is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4xdl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XDL FirstGlance]. <br>
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Authors: MACKENZIE, A., PIKE, A.C.W., DONG, Y.Y., MUKHOPADHYAY, S., RUDA, G.F., BRENNAN, P.E., ARROWSMITH, C.H., EDWARDS, A.M., BOUNTRA, C., BURGESS-BROWN, N.A., CARPENTER, E.P., Structural Genomics Consortium (SGC)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=40D:3-[2-BROMANYL-4-(TRIFLUOROMETHYL)PHENOXY]-N-METHYL-3-PHENYL-PROPAN-1-AMINE'>40D</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bw5|4bw5]]</td></tr>
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Description:
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xdl RCSB], [http://www.ebi.ac.uk/pdbsum/4xdl PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Ruda, G.F]]
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== Function ==
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[[Category: Pike, A.C.W]]
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[[http://www.uniprot.org/uniprot/KCNKA_HUMAN KCNKA_HUMAN]] Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
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[[Category: Burgess-Brown, N.A]]
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__TOC__
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[[Category: Mukhopadhyay, S]]
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</StructureSection>
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[[Category: Carpenter, E.P]]
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[[Category: ARROWSMITH, C H]]
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[[Category: Bountra, C]]
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[[Category: BOUNTRA, C]]
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[[Category: Mackenzie, A]]
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[[Category: BRENNAN, P E]]
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[[Category: Arrowsmith, C.H]]
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[[Category: BURGESS-BROWN, N A]]
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[[Category: Dong, Y.Y]]
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[[Category: CARPENTER, E P]]
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[[Category: Edwards, A.M]]
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[[Category: DONG, Y Y]]
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[[Category: Brennan, P.E]]
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[[Category: EDWARDS, A M]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: MACKENZIE, A]]
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[[Category: MUKHOPADHYAY, S]]
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[[Category: PIKE, A C.W]]
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[[Category: RUDA, G F]]
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[[Category: Structural genomic]]
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[[Category: K2p]]
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[[Category: Membrane protein]]
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[[Category: Outward rectification]]
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[[Category: Sgc]]
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[[Category: Transport protein]]

Revision as of 12:17, 18 March 2015

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with a brominated fluoxetine derivative.

4xdl, resolution 3.50Å

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