This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2y4l
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH Manganese and GDP== | ==MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH Manganese and GDP== | ||
<StructureSection load='2y4l' size='340' side='right' caption='[[2y4l]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='2y4l' size='340' side='right' caption='[[2y4l]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y4l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2y4l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhom4 Rhom4]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2xw4 2xw4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y4L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y4L FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y4j|2y4j]], [[2bo6|2bo6]], [[2bo7|2bo7]], [[2y4m|2y4m]], [[2bo8|2bo8]], [[2y4k|2y4k]], [[2bo4|2bo4]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2y4j|2y4j]], [[2bo6|2bo6]], [[2bo7|2bo7]], [[2y4m|2y4m]], [[2bo8|2bo8]], [[2y4k|2y4k]], [[2bo4|2bo4]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mannosyl-3-phosphoglycerate_synthase Mannosyl-3-phosphoglycerate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.217 2.4.1.217] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4l OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y4l RCSB], [http://www.ebi.ac.uk/pdbsum/2y4l PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y4l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y4l OCA], [http://pdbe.org/2y4l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y4l RCSB], [http://www.ebi.ac.uk/pdbsum/2y4l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y4l ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MGS_RHOMR MGS_RHOMR]] Involved in the biosynthesis of the stress protectant 2-O-alpha-D-mannosyl glycerate (MG) which is produced in response to growth at supraoptimal temperature and salinity, and protects several enzymes against inactivation by temperature, freeze-drying and osmotic stress. Catalyzes the condensation of alpha-GDP-D-mannose (GDP-Man) with D-glycerate to produce alpha-mannosyl-D-glycerate. It is specific for GDP-Man, but it can also use alpha-GDP-D-glucose (GDP-Glc), beta-GDP-D-fuctose, alpha-UDP-D-mannose and alpha-UDP-D-glucose as sugar donors. It is specific for D-glycerate, but it can also use D-lactate and glycolate as sugar acceptors. This reaction occurs with a net retention of anomeric configuration; the newly formed glycosidic linkage has the same alpha configuration as the sugar donor.<ref>PMID:10585410</ref> <ref>PMID:15951819</ref> <ref>PMID:21288903</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 16: | Line 19: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2y4l" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 21: | Line 25: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Mannosyl-3-phosphoglycerate synthase]] | [[Category: Mannosyl-3-phosphoglycerate synthase]] | ||
| - | [[Category: | + | [[Category: Rhom4]] |
[[Category: Barry, C S]] | [[Category: Barry, C S]] | ||
[[Category: Davies, G J]] | [[Category: Davies, G J]] | ||
Revision as of 05:16, 5 August 2016
MANNOSYLGLYCERATE SYNTHASE IN COMPLEX WITH Manganese and GDP
| |||||||||||
