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2y92
From Proteopedia
(Difference between revisions)
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==CRYSTAL STRUCTURE OF MAL ADAPTOR PROTEIN== | ==CRYSTAL STRUCTURE OF MAL ADAPTOR PROTEIN== | ||
<StructureSection load='2y92' size='340' side='right' caption='[[2y92]], [[Resolution|resolution]] 3.01Å' scene=''> | <StructureSection load='2y92' size='340' side='right' caption='[[2y92]], [[Resolution|resolution]] 3.01Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2y92]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y92 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y92 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y92 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y92 RCSB], [http://www.ebi.ac.uk/pdbsum/2y92 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y92 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y92 OCA], [http://pdbe.org/2y92 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y92 RCSB], [http://www.ebi.ac.uk/pdbsum/2y92 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y92 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN]] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2y92" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[TIR domain-containing adaptor protein|TIR domain-containing adaptor protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Kobe, B]] | [[Category: Kobe, B]] | ||
[[Category: Martin, J L]] | [[Category: Martin, J L]] | ||
Revision as of 13:42, 5 August 2016
CRYSTAL STRUCTURE OF MAL ADAPTOR PROTEIN
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