2g9c
From Proteopedia
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|PDB= 2g9c |SIZE=350|CAPTION= <scene name='initialview01'>2g9c</scene>, resolution 1.70Å | |PDB= 2g9c |SIZE=350|CAPTION= <scene name='initialview01'>2g9c</scene>, resolution 1.70Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene> | + | |LIGAND= <scene name='pdbligand=3AY:PYRIMIDINE-2,4,6-TRIAMINE'>3AY</scene>, <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g9c OCA], [http://www.ebi.ac.uk/pdbsum/2g9c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g9c RCSB]</span> | ||
}} | }} | ||
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[[Category: Gilbert, S D.]] | [[Category: Gilbert, S D.]] | ||
[[Category: Mediatore, S J.]] | [[Category: Mediatore, S J.]] | ||
| - | [[Category: 3AY]] | ||
| - | [[Category: ACT]] | ||
| - | [[Category: NCO]] | ||
[[Category: mrna]] | [[Category: mrna]] | ||
[[Category: riboswitch]] | [[Category: riboswitch]] | ||
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[[Category: triaminopyrimidine]] | [[Category: triaminopyrimidine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:13:32 2008'' |
Revision as of 00:13, 31 March 2008
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| , resolution 1.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Modified pyrimidines Specifically bind the purine riboswitch
Overview
The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.
About this Structure
2G9C is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Modified pyrimidines specifically bind the purine riboswitch., Gilbert SD, Mediatore SJ, Batey RT, J Am Chem Soc. 2006 Nov 8;128(44):14214-5. PMID:17076468
Page seeded by OCA on Mon Mar 31 03:13:32 2008
