2j68

From Proteopedia

Revision as of 08:49, 30 October 2007

BACTERIAL DYNAMIN-LIKE PROTEIN BDLP, GDP BOUND

Overview

Dynamins form a superfamily of large mechano-chemical GTPases that, includes the classical dynamins and dynamin-like proteins (DLPs). They are, found throughout the Eukarya, functioning in core cellular processes such, as endocytosis and organelle division. Many bacteria are predicted by, sequence to possess large GTPases with the same multidomain architecture, that is found in DLPs. Mechanistic dissection of dynamin family members, has been impeded by a lack of high-resolution structural data currently, restricted to the GTPase and pleckstrin homology domains, and the, dynamin-related human guanylate-binding protein. Here we present the, crystal structure of a cyanobacterial DLP in both nucleotide-free and, GDP-associated conformation. The bacterial DLP shows dynamin-like, qualities, ... [(full description)]

About this Structure

2J68 is a [Single protein] structure of sequence from [Nostoc punctiforme] with GDP as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

A bacterial dynamin-like protein., Low HH, Lowe J, Nature. 2006 Dec 7;444(7120):766-9. Epub 2006 Nov 22. PMID:17122778

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