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2gjc

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|PDB= 2gjc |SIZE=350|CAPTION= <scene name='initialview01'>2gjc</scene>, resolution 1.82&Aring;
|PDB= 2gjc |SIZE=350|CAPTION= <scene name='initialview01'>2gjc</scene>, resolution 1.82&Aring;
|SITE=
|SITE=
-
|LIGAND= <scene name='pdbligand=AHZ:ADENOSINE DIPHOSPHATE 5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC ACID'>AHZ</scene>
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|LIGAND= <scene name='pdbligand=AHZ:ADENOSINE+DIPHOSPHATE+5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC+ACID'>AHZ</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= THI4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
|GENE= THI4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
 +
|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjc OCA], [http://www.ebi.ac.uk/pdbsum/2gjc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gjc RCSB]</span>
}}
}}
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[[Category: Ealick, S E.]]
[[Category: Ealick, S E.]]
[[Category: Jurgenson, C T.]]
[[Category: Jurgenson, C T.]]
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[[Category: AHZ]]
 
[[Category: glutathione reductase type ii family]]
[[Category: glutathione reductase type ii family]]
[[Category: mitochondria dna repair]]
[[Category: mitochondria dna repair]]
[[Category: thiazole synthase]]
[[Category: thiazole synthase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:05:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:17:30 2008''

Revision as of 00:17, 31 March 2008

Image:2gjc.gif


PDB ID 2gjc

Drag the structure with the mouse to rotate
, resolution 1.82Å
Ligands:
Gene: THI4 (Saccharomyces cerevisiae)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Thiazole Synthase in Saccharomyces cerevisiae at 1.82 A resolution


Overview

The structure of thiazole synthase (Thi4) from Saccharomyces cerevisiae was determined to 1.8 A resolution. Thi4 exists as an octamer with two monomers in the asymmetric unit. The structure reveals the presence of a tightly bound adenosine diphospho-5-(beta-ethyl)-4-methylthiazole-2-carboxylic acid at the active site. The isolation of this reaction product identifies NAD as the most likely precursor and provides the first mechanistic insights into the biosynthesis of the thiamin thiazole in eukaryotes. Additionally, the Thi4 structure reveals the first protein structure with a GR(2) domain that binds NAD instead of FAD, raising interesting questions about how this protein evolved from a flavoenzyme to a NAD binding enzyme.

About this Structure

2GJC is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural insights into the function of the thiamin biosynthetic enzyme Thi4 from Saccharomyces cerevisiae., Jurgenson CT, Chatterjee A, Begley TP, Ealick SE, Biochemistry. 2006 Sep 19;45(37):11061-70. PMID:16964967

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