3srk
From Proteopedia
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==A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase== | ==A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase== | ||
<StructureSection load='3srk' size='340' side='right' caption='[[3srk]], [[Resolution|resolution]] 2.65Å' scene=''> | <StructureSection load='3srk' size='340' side='right' caption='[[3srk]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3srk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3srk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leime Leime]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SRK FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LSA:1,2-BENZISOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>LSA</scene>, <scene name='pdbligand=PTK:PYRENE-1,3,6,8-TETRASULFONIC+ACID'>PTK</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LSA:1,2-BENZISOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>LSA</scene>, <scene name='pdbligand=PTK:PYRENE-1,3,6,8-TETRASULFONIC+ACID'>PTK</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pkl|1pkl]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pkl|1pkl]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5665 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PYK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5665 LEIME])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_kinase Pyruvate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.40 2.7.1.40] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3srk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3srk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3srk RCSB], [http://www.ebi.ac.uk/pdbsum/3srk PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3srk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3srk OCA], [http://pdbe.org/3srk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3srk RCSB], [http://www.ebi.ac.uk/pdbsum/3srk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3srk ProSAT]</span></td></tr> |
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Leime]] |
[[Category: Pyruvate kinase]] | [[Category: Pyruvate kinase]] | ||
[[Category: Auld, D S]] | [[Category: Auld, D S]] | ||
Revision as of 16:59, 11 August 2016
A new class of suicide inhibitor blocks nucleotide binding to pyruvate kinase
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