3vp7
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of the beta-alpha repeated, autophagy-specific (BARA) domain of Vps30/Atg6== | ==Crystal structure of the beta-alpha repeated, autophagy-specific (BARA) domain of Vps30/Atg6== | ||
<StructureSection load='3vp7' size='340' side='right' caption='[[3vp7]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='3vp7' size='340' side='right' caption='[[3vp7]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3vp7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3vp7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VP7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VP7 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VPS30, APG6, ATG6, VPT30, YPL120W, LPH7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VPS30, APG6, ATG6, VPT30, YPL120W, LPH7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vp7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vp7 RCSB], [http://www.ebi.ac.uk/pdbsum/3vp7 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vp7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vp7 OCA], [http://pdbe.org/3vp7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vp7 RCSB], [http://www.ebi.ac.uk/pdbsum/3vp7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vp7 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BECN1_YEAST BECN1_YEAST]] Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Plays also a role in regulation of filamentous growth.<ref>PMID:11157979</ref> <ref>PMID:11689437</ref> <ref>PMID:12244127</ref> <ref>PMID:16267277</ref> <ref>PMID:17404498</ref> <ref>PMID:17700056</ref> <ref>PMID:18182384</ref> <ref>PMID:18701704</ref> <ref>PMID:19131141</ref> <ref>PMID:22437838</ref> <ref>PMID:23878393</ref> <ref>PMID:8224160</ref> <ref>PMID:9105038</ref> <ref>PMID:9712845</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Baker's yeast]] |
[[Category: Adachi, W]] | [[Category: Adachi, W]] | ||
[[Category: Fujioka, Y]] | [[Category: Fujioka, Y]] | ||
Revision as of 11:50, 11 August 2016
Crystal structure of the beta-alpha repeated, autophagy-specific (BARA) domain of Vps30/Atg6
| |||||||||||
