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2h3b
From Proteopedia
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|PDB= 2h3b |SIZE=350|CAPTION= <scene name='initialview01'>2h3b</scene>, resolution 1.95Å | |PDB= 2h3b |SIZE=350|CAPTION= <scene name='initialview01'>2h3b</scene>, resolution 1.95Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span> |
|GENE= Nampt, Pbef1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= Nampt, Pbef1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2h3d|2H3D]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h3b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h3b OCA], [http://www.ebi.ac.uk/pdbsum/2h3b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h3b RCSB]</span> | ||
}} | }} | ||
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[[Category: Wolberger, C.]] | [[Category: Wolberger, C.]] | ||
[[Category: Zhang, X.]] | [[Category: Zhang, X.]] | ||
| - | [[Category: SO4]] | ||
[[Category: apoenzyme]] | [[Category: apoenzyme]] | ||
[[Category: type ii phsophoribosyltransferase]] | [[Category: type ii phsophoribosyltransferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:24:49 2008'' |
Revision as of 00:24, 31 March 2008
| |||||||
| , resolution 1.95Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | Nampt, Pbef1 (Mus musculus) | ||||||
| Activity: | Nicotinamide phosphoribosyltransferase, with EC number 2.4.2.12 | ||||||
| Related: | 2H3D
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1
Overview
Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.
About this Structure
2H3B is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme., Wang T, Zhang X, Bheda P, Revollo JR, Imai S, Wolberger C, Nat Struct Mol Biol. 2006 Jul;13(7):661-2. Epub 2006 Jun 18. PMID:16783373
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