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2h5a
From Proteopedia
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|PDB= 2h5a |SIZE=350|CAPTION= <scene name='initialview01'>2h5a</scene>, resolution 1.72Å | |PDB= 2h5a |SIZE=350|CAPTION= <scene name='initialview01'>2h5a</scene>, resolution 1.72Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=X1P:1-O-PHOSPHONO-ALPHA-D-XYLOPYRANOSE'>X1P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= algC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa]) | |GENE= algC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1k35|1K35]], [[1k2y|1K2Y]], [[1p5d|1P5D]], [[1p5g|1P5G]], [[1pcj|1PCJ]], [[1pcm|1PCM]], [[2h4l|2H4L]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5a OCA], [http://www.ebi.ac.uk/pdbsum/2h5a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h5a RCSB]</span> | ||
}} | }} | ||
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[[Category: Regni, C.]] | [[Category: Regni, C.]] | ||
[[Category: Shackelford, G S.]] | [[Category: Shackelford, G S.]] | ||
| - | [[Category: X1P]] | ||
| - | [[Category: ZN]] | ||
[[Category: enzyme-ligand complex]] | [[Category: enzyme-ligand complex]] | ||
[[Category: inhibitor]] | [[Category: inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:25:40 2008'' |
Revision as of 00:25, 31 March 2008
| |||||||
| , resolution 1.72Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | algC (Pseudomonas aeruginosa) | ||||||
| Related: | 1K35, 1K2Y, 1P5D, 1P5G, 1PCJ, 1PCM, 2H4L
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Complex of the enzyme PMM/PGM with xylose 1-phosphate
Overview
Two complexes of the enzyme phosphomannomutase/phosphoglucomutase (PMM/PGM) from Pseudomonas aeruginosa with a slow substrate and with an inhibitor have been characterized by X-ray crystallography. Both ligands induce an interdomain rearrangement in the enzyme that creates a highly buried active site. Comparisons with enzyme-substrate complexes show that the inhibitor xylose 1-phosphate utilizes many of the previously observed enzyme-ligand interactions. In contrast, analysis of the ribose 1-phosphate complex reveals a combination of new and conserved enzyme-ligand interactions for binding. The ability of PMM/PGM to accommodate these two pentose phosphosugars in its active site may be relevant for future efforts towards inhibitor design.
About this Structure
2H5A is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
Complexes of the enzyme phosphomannomutase/phosphoglucomutase with a slow substrate and an inhibitor., Regni C, Shackelford GS, Beamer LJ, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt, 8):722-6. Epub 2006 Jul 24. PMID:16880541
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