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2hci

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|PDB= 2hci |SIZE=350|CAPTION= <scene name='initialview01'>2hci</scene>, resolution 1.81&Aring;
|PDB= 2hci |SIZE=350|CAPTION= <scene name='initialview01'>2hci</scene>, resolution 1.81&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene> and <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
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|LIGAND= <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO3:SULFITE+ION'>SO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=[[1m8a|1M8A]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hci OCA], [http://www.ebi.ac.uk/pdbsum/2hci PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hci RCSB]</span>
}}
}}
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[[Category: Malik, Z A.]]
[[Category: Malik, Z A.]]
[[Category: Tack, B F.]]
[[Category: Tack, B F.]]
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[[Category: PEG]]
 
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[[Category: SO3]]
 
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[[Category: SO4]]
 
[[Category: dimer]]
[[Category: dimer]]
[[Category: macrophage inflammatory protein-3a]]
[[Category: macrophage inflammatory protein-3a]]
[[Category: space group i4]]
[[Category: space group i4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:15:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:28:30 2008''

Revision as of 00:28, 31 March 2008

Image:2hci.gif


PDB ID 2hci

Drag the structure with the mouse to rotate
, resolution 1.81Å
Ligands: , ,
Related: 1M8A


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Structure of Human Mip-3a Chemokine


Overview

The structure of the human macrophage inflammatory protein-3alpha (MIP-3alpha) has been determined at 1.81 angstroms resolution by X-ray crystallography. The dimer crystallized in the tetragonal space group I4, with unit-cell parameters a = b = 83.99, c = 57.20 angstroms. The crystals exhibit two molecules in the asymmetric unit. The structure was solved by the molecular-replacement method and the model was refined to a conventional R value of 20.6% (R(free) = 25.7%). MIP-3alpha possesses the same monomeric structure as previously described for other chemokines. However, in addition to limited structural changes in the beta1-beta2 hairpin of monomer B, the electron density is fully defined for a few extra residues at the N- and C-termini of monomer A and the C-terminus of monomer B compared with MIP-3alpha in space group P6(1). As the N-terminal and loop regions have been shown to be critical for receptor binding and signaling, this additional structural information may help in determining the basis of the CCR6 selectivity of MIP-3alpha.

About this Structure

2HCI is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.

Reference

Structure of human MIP-3alpha chemokine., Malik ZA, Tack BF, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jul 1;62(Pt, 7):631-4. Epub 2006 Jun 30. PMID:16820679

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