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2hnx
From Proteopedia
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|PDB= 2hnx |SIZE=350|CAPTION= <scene name='initialview01'>2hnx</scene>, resolution 1.50Å | |PDB= 2hnx |SIZE=350|CAPTION= <scene name='initialview01'>2hnx</scene>, resolution 1.50Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= FABP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= FABP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hnx OCA], [http://www.ebi.ac.uk/pdbsum/2hnx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hnx RCSB]</span> | ||
}} | }} | ||
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[[Category: Qiu, X.]] | [[Category: Qiu, X.]] | ||
[[Category: Tardie, M.]] | [[Category: Tardie, M.]] | ||
| - | [[Category: ACY]] | ||
| - | [[Category: PLM]] | ||
| - | [[Category: PO4]] | ||
[[Category: fatty acid binding protein]] | [[Category: fatty acid binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:32:52 2008'' |
Revision as of 00:32, 31 March 2008
| |||||||
| , resolution 1.50Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | FABP4 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of aP2
Overview
Human adipocyte lipid-binding protein (aP2) belongs to a family of intracellular lipid-binding proteins involved in the transport and storage of lipids. Here, the crystal structure of human aP2 with a bound palmitate is described at 1.5 A resolution. Unlike the known crystal structure of murine aP2 in complex with palmitate, this structure shows that the fatty acid is in a folded conformation and that the loop containing Phe57 acts as a lid to regulate ligand binding by excluding solvent exposure to the central binding cavity.
About this Structure
2HNX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1058-60. Epub 2006 Oct 25. PMID:17077479
Page seeded by OCA on Mon Mar 31 03:32:52 2008
