4oyq
From Proteopedia
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==(6-isothiocyanatohexyl)benzene inhibitor complexed with Macrophage Migration Inhibitory Factor== | ==(6-isothiocyanatohexyl)benzene inhibitor complexed with Macrophage Migration Inhibitory Factor== | ||
<StructureSection load='4oyq' size='340' side='right' caption='[[4oyq]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='4oyq' size='340' side='right' caption='[[4oyq]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wns|3wns]], [[3wnr|3wnr]], [[3wnt|3wnt]], [[4osf|4osf]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wns|3wns]], [[3wnr|3wnr]], [[3wnt|3wnt]], [[4osf|4osf]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MIF, GLIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oyq RCSB], [http://www.ebi.ac.uk/pdbsum/4oyq PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oyq OCA], [http://pdbe.org/4oyq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oyq RCSB], [http://www.ebi.ac.uk/pdbsum/4oyq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oyq ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref> | [[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref> | ||
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| + | ==See Also== | ||
| + | *[[Macrophage inhibitory factor|Macrophage inhibitory factor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 19:23, 11 August 2016
(6-isothiocyanatohexyl)benzene inhibitor complexed with Macrophage Migration Inhibitory Factor
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