2huy
From Proteopedia
(Difference between revisions)
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|PDB= 2huy |SIZE=350|CAPTION= <scene name='initialview01'>2huy</scene>, resolution 1.700Å | |PDB= 2huy |SIZE=350|CAPTION= <scene name='initialview01'>2huy</scene>, resolution 1.700Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=YVN:N-({(1R,2R,3S)-2-[(METHYLAMINO)CARBONYL]-3-[4-(PHOSPHONOOXY)PHENYL]CYCLOPROPYL}CARBONYL)-L-VALYL-L-ASPARTAMIDE'>YVN | + | |LIGAND= <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=YVN:N-({(1R,2R,3S)-2-[(METHYLAMINO)CARBONYL]-3-[4-(PHOSPHONOOXY)PHENYL]CYCLOPROPYL}CARBONYL)-L-VALYL-L-ASPARTAMIDE'>YVN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2huw|2HUW]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2huy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2huy OCA], [http://www.ebi.ac.uk/pdbsum/2huy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2huy RCSB]</span> | ||
}} | }} | ||
'''X-ray crystal structure of the complex between the Grb2-SH2 domain and a flexible ligand, fpYVN.''' | '''X-ray crystal structure of the complex between the Grb2-SH2 domain and a flexible ligand, fpYVN.''' | ||
| - | |||
| - | ==Disease== | ||
| - | Known diseases associated with this structure: Central hypoventilation syndrome, congenital OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=100790 100790]], Haddad syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=100790 100790]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Benfield, A P.]] | [[Category: Benfield, A P.]] | ||
[[Category: Martin, S F.]] | [[Category: Martin, S F.]] | ||
| - | [[Category: FMT]] | ||
| - | [[Category: YVN]] | ||
[[Category: constrained]] | [[Category: constrained]] | ||
[[Category: entropy]] | [[Category: entropy]] | ||
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[[Category: ligand preorganization]] | [[Category: ligand preorganization]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:35:50 2008'' |
Revision as of 00:35, 31 March 2008
| |||||||
| , resolution 1.700Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | GRB2, ASH (Homo sapiens) | ||||||
| Related: | 2HUW
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-ray crystal structure of the complex between the Grb2-SH2 domain and a flexible ligand, fpYVN.
About this Structure
2HUY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions., Benfield AP, Teresk MG, Plake HR, DeLorbe JE, Millspaugh LE, Martin SF, Angew Chem Int Ed Engl. 2006 Oct 20;45(41):6830-5. PMID:17001728
Page seeded by OCA on Mon Mar 31 03:35:50 2008
