This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2huy
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2huy |SIZE=350|CAPTION= <scene name='initialview01'>2huy</scene>, resolution 1.700Å | |PDB= 2huy |SIZE=350|CAPTION= <scene name='initialview01'>2huy</scene>, resolution 1.700Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=YVN:N-({(1R,2R,3S)-2-[(METHYLAMINO)CARBONYL]-3-[4-(PHOSPHONOOXY)PHENYL]CYCLOPROPYL}CARBONYL)-L-VALYL-L-ASPARTAMIDE'>YVN | + | |LIGAND= <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=YVN:N-({(1R,2R,3S)-2-[(METHYLAMINO)CARBONYL]-3-[4-(PHOSPHONOOXY)PHENYL]CYCLOPROPYL}CARBONYL)-L-VALYL-L-ASPARTAMIDE'>YVN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= GRB2, ASH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2huw|2HUW]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2huy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2huy OCA], [http://www.ebi.ac.uk/pdbsum/2huy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2huy RCSB]</span> | ||
}} | }} | ||
'''X-ray crystal structure of the complex between the Grb2-SH2 domain and a flexible ligand, fpYVN.''' | '''X-ray crystal structure of the complex between the Grb2-SH2 domain and a flexible ligand, fpYVN.''' | ||
| - | |||
| - | ==Disease== | ||
| - | Known diseases associated with this structure: Central hypoventilation syndrome, congenital OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=100790 100790]], Haddad syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=100790 100790]] | ||
==About this Structure== | ==About this Structure== | ||
| Line 24: | Line 24: | ||
[[Category: Benfield, A P.]] | [[Category: Benfield, A P.]] | ||
[[Category: Martin, S F.]] | [[Category: Martin, S F.]] | ||
| - | [[Category: FMT]] | ||
| - | [[Category: YVN]] | ||
[[Category: constrained]] | [[Category: constrained]] | ||
[[Category: entropy]] | [[Category: entropy]] | ||
| Line 32: | Line 30: | ||
[[Category: ligand preorganization]] | [[Category: ligand preorganization]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:35:50 2008'' |
Revision as of 00:35, 31 March 2008
| |||||||
| , resolution 1.700Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | GRB2, ASH (Homo sapiens) | ||||||
| Related: | 2HUW
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-ray crystal structure of the complex between the Grb2-SH2 domain and a flexible ligand, fpYVN.
About this Structure
2HUY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Ligand preorganization may be accompanied by entropic penalties in protein-ligand interactions., Benfield AP, Teresk MG, Plake HR, DeLorbe JE, Millspaugh LE, Martin SF, Angew Chem Int Ed Engl. 2006 Oct 20;45(41):6830-5. PMID:17001728
Page seeded by OCA on Mon Mar 31 03:35:50 2008
