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Peptide N-glycanase

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== Function ==
== Function ==
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'''Peptide N-glycanase''' (PNG) cleaves oligosaccharides from misfolded proteins and prepares them for degradation. PNG cleaves at beta-aspartyl glucosamine bond to remove a glycan moiety from glycoprotein substrate. PNG is present in prokaryotes and eukaryotes. PNG N terminal PUB domain interacts with the AAA ATPase protein p97 is a central component in the ubiquitin-proteasome system.
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'''Peptide N-glycanase''' (PNG) cleaves oligosaccharides from misfolded proteins and prepares them for degradation. PNG cleaves at β-aspartyl glucosamine bond to remove a glycan moiety from glycoprotein substrate<ref>PMID:17116467</ref>. PNG is present in prokaryotes and eukaryotes. PNG N terminal PUB domain interacts with the AAA ATPase protein p97 is a central component in the ubiquitin-proteasome system.
== Disease ==
== Disease ==

Revision as of 08:41, 20 June 2016

Yeast PNGase catalytic domain (grey) complex with Rad23 (green), Zn+2 (grey) and Cl- (green) ions (PDB code 2f4m).

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3D Structures of PNGase

Updated on 20-June-2016

References

  1. ↑ Tanabe K, Lennarz WJ, Suzuki T. A cytoplasmic peptide: N-glycanase. Methods Enzymol. 2006;415:46-55. PMID:17116467 doi:http://dx.doi.org/10.1016/S0076-6879(06)15004-1

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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