2ikq
From Proteopedia
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|PDB= 2ikq |SIZE=350|CAPTION= <scene name='initialview01'>2ikq</scene>, resolution 2.609Å | |PDB= 2ikq |SIZE=350|CAPTION= <scene name='initialview01'>2ikq</scene>, resolution 2.609Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene> | + | |LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= Sts-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | |GENE= Sts-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[2h0q|2H0Q]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ikq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ikq OCA], [http://www.ebi.ac.uk/pdbsum/2ikq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ikq RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Chen, Y.]] | [[Category: Chen, Y.]] | ||
[[Category: Nassar, N.]] | [[Category: Nassar, N.]] | ||
| - | [[Category: | + | [[Category: acid phosphatase]] |
[[Category: immune system]] | [[Category: immune system]] | ||
| - | [[Category: pgm | + | [[Category: pgm]] |
| + | [[Category: phospho-histidine enzyme]] | ||
[[Category: signaling protein]] | [[Category: signaling protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:45:33 2008'' |
Revision as of 00:45, 31 March 2008
| |||||||
| , resolution 2.609Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | Sts-1 (Mus musculus) | ||||||
| Related: | 2H0Q
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of mouse Sts-1 PGM domain in complex with phosphate
Overview
Precise signaling by the T cell receptor (TCR) is crucial for a proper immune response. To ensure that T cells respond appropriately to antigenic stimuli, TCR signaling pathways are subject to multiple levels of regulation. Sts-1 negatively regulates signaling pathways downstream of the TCR by an unknown mechanism(s). Here, we demonstrate that Sts-1 is a phosphatase that can target the tyrosine kinase Zap-70 among other proteins. The X-ray structure of the Sts-1 C terminus reveals that it has homology to members of the phosphoglycerate mutase/acid phosphatase (PGM/AcP) family of enzymes, with residues known to be important for PGM/AcP catalytic activity conserved in nature and position in Sts-1. Point mutations that impair Sts-1 phosphatase activity in vitro also impair the ability of Sts-1 to regulate TCR signaling in T cells. These observations reveal a PGM/AcP-like enzyme activity involved in the control of antigen receptor signaling.
About this Structure
2IKQ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling., Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N, Mol Cell. 2007 Aug 3;27(3):486-97. PMID:17679096
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