2iuu

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|PDB= 2iuu |SIZE=350|CAPTION= <scene name='initialview01'>2iuu</scene>, resolution 2.9&Aring;
|PDB= 2iuu |SIZE=350|CAPTION= <scene name='initialview01'>2iuu</scene>, resolution 2.9&Aring;
|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+F'>AC1</scene>
|SITE= <scene name='pdbsite=AC1:Adp+Binding+Site+For+Chain+F'>AC1</scene>
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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[[Category: transmembrane]]
[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:33:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:22:38 2008''

Revision as of 13:22, 23 March 2008

Image:2iuu.gif


PDB ID 2iuu

Drag the structure with the mouse to rotate
, resolution 2.9Å
Sites:
Ligands:
Coordinates: save as pdb, mmCIF, xml



P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER


Overview

FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction. We present crystal structures of the FtsK motor domain monomer, showing that it has a RecA-like core, the FtsK hexamer, and also showing that it is a ring with a large central annulus and a dodecamer consisting of two hexamers, head to head. Electron microscopy (EM) demonstrates the DNA-dependent existence of hexamers in solution and shows that duplex DNA passes through the middle of each ring. Comparison of FtsK monomer structures from two different crystal forms highlights a conformational change that we propose is the structural basis for a rotary inchworm mechanism of DNA translocation.

About this Structure

2IUU is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635

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