2j6x
From Proteopedia
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|PDB= 2j6x |SIZE=350|CAPTION= <scene name='initialview01'>2j6x</scene>, resolution 2.10Å | |PDB= 2j6x |SIZE=350|CAPTION= <scene name='initialview01'>2j6x</scene>, resolution 2.10Å | ||
|SITE= <scene name='pdbsite=AC1:Fmn+Binding+Site+For+Chain+H'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Fmn+Binding+Site+For+Chain+H'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/ | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lactate_2-monooxygenase Lactate 2-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.12.4 1.13.12.4] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j6x OCA], [http://www.ebi.ac.uk/pdbsum/2j6x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j6x RCSB]</span> | ||
}} | }} | ||
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The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX)., Leiros I, Wang E, Rasmussen T, Oksanen E, Repo H, Petersen SB, Heikinheimo P, Hough E, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1185-90. Epub 2006 Nov 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17142893 17142893] | The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX)., Leiros I, Wang E, Rasmussen T, Oksanen E, Repo H, Petersen SB, Heikinheimo P, Hough E, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1185-90. Epub 2006 Nov 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17142893 17142893] | ||
[[Category: Aerococcus viridans]] | [[Category: Aerococcus viridans]] | ||
| + | [[Category: Lactate 2-monooxygenase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Transferred entry: 1 13 12 4]] | ||
[[Category: Heikinheimo, P.]] | [[Category: Heikinheimo, P.]] | ||
[[Category: Hough, E.]] | [[Category: Hough, E.]] | ||
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[[Category: Repo, H.]] | [[Category: Repo, H.]] | ||
[[Category: Wang, E.]] | [[Category: Wang, E.]] | ||
| - | [[Category: FMN]] | ||
| - | [[Category: ZN]] | ||
[[Category: biosensor]] | [[Category: biosensor]] | ||
[[Category: flavoenzyme]] | [[Category: flavoenzyme]] | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:53:53 2008'' |
Revision as of 00:53, 31 March 2008
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| , resolution 2.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , | ||||||
| Activity: | Lactate 2-monooxygenase, with EC number 1.13.12.4 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE CRYSTAL STRUCTURE OF LACTATE OXIDASE
Overview
The crystal structure of L-lactate oxidase (LOX) from Aerococcus viridans has been determined at 2.1 A resolution. LOX catalyzes the flavin mononucleotide (FMN) dependent oxidation of lactate to pyruvate and hydrogen peroxide. LOX belongs to the alpha-hydroxy-acid oxidase flavoenzyme family; members of which bind similar substrates and to some extent have conserved catalytic properties and structural motifs. LOX crystallized as two tightly packed tetramers in the asymmetric unit, each having fourfold symmetry. The present structure shows a conserved FMN coordination, but also reveals novel residues involved in substrate binding compared with other family members.
About this Structure
2J6X is a Single protein structure of sequence from Aerococcus viridans. Full crystallographic information is available from OCA.
Reference
The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX)., Leiros I, Wang E, Rasmussen T, Oksanen E, Repo H, Petersen SB, Heikinheimo P, Hough E, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1185-90. Epub 2006 Nov 4. PMID:17142893
Page seeded by OCA on Mon Mar 31 03:53:53 2008
