4o9h
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Structure of Interleukin-6 in complex with a Camelid Fab fragment== |
| - | + | <StructureSection load='4o9h' size='340' side='right' caption='[[4o9h]], [[Resolution|resolution]] 2.42Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4o9h]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O9H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o9h RCSB], [http://www.ebi.ac.uk/pdbsum/4o9h PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Disease == | |
| - | [[ | + | [[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Blanchetot, C]] | ||
[[Category: Cambillau, C]] | [[Category: Cambillau, C]] | ||
| - | [[Category: | + | [[Category: Desmyter, A]] |
[[Category: Dreier, T]] | [[Category: Dreier, T]] | ||
| - | [[Category: Kretz-Rommel, A]] | ||
| - | [[Category: Hultberg, A]] | ||
| - | [[Category: Roovers, R.C]] | ||
| - | [[Category: De Haard, H.J.W]] | ||
| - | [[Category: Sadi, A.S]] | ||
[[Category: Hemrika, W]] | [[Category: Hemrika, W]] | ||
| - | [[Category: | + | [[Category: Hultberg, A]] |
| + | [[Category: Klarenbeek, A]] | ||
| + | [[Category: Kretz-rommel, A]] | ||
[[Category: Ongenae, N]] | [[Category: Ongenae, N]] | ||
| - | [[Category: | + | [[Category: Roovers, R C]] |
| - | [[Category: | + | [[Category: Sadi, A S]] |
[[Category: Schragel, G]] | [[Category: Schragel, G]] | ||
| + | [[Category: Spinelli, S]] | ||
| + | [[Category: Wijdenes, J]] | ||
| + | [[Category: Haard, H J.W De]] | ||
| + | [[Category: Fab: all beta protein]] | ||
| + | [[Category: Il6: all alpha protein]] | ||
| + | [[Category: Immune system]] | ||
Revision as of 12:57, 15 April 2015
Structure of Interleukin-6 in complex with a Camelid Fab fragment
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