2jdk
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2jdk |SIZE=350|CAPTION= <scene name='initialview01'>2jdk</scene>, resolution 1.10Å | |PDB= 2jdk |SIZE=350|CAPTION= <scene name='initialview01'>2jdk</scene>, resolution 1.10Å | ||
|SITE= <scene name='pdbsite=AC1:T45+Binding+Site+For+Chain+C'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:T45+Binding+Site+For+Chain+C'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T45:METHYL+2H-1,2,3-TRIAZOLE-4-CARBOXYLATE'>T45</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1gzt|1GZT]], [[1our|1OUR]], [[1ous|1OUS]], [[1oux|1OUX]], [[1ovp|1OVP]], [[1ovs|1OVS]], [[1oxc|1OXC]], [[1uzv|1UZV]], [[1w43|1W43]], [[1w8f|1W8F]], [[1w8h|1W8H]], [[2boj|2BOJ]], [[2bp6|2BP6]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jdk OCA], [http://www.ebi.ac.uk/pdbsum/2jdk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jdk RCSB]</span> | ||
}} | }} | ||
| Line 31: | Line 34: | ||
[[Category: Sabin, C.]] | [[Category: Sabin, C.]] | ||
[[Category: Wimmerova, M.]] | [[Category: Wimmerova, M.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: FUC]] | ||
| - | [[Category: SO4]] | ||
[[Category: cystic fibrosis]] | [[Category: cystic fibrosis]] | ||
[[Category: glycomimetic]] | [[Category: glycomimetic]] | ||
| Line 39: | Line 39: | ||
[[Category: pseudomonas aeruginosa]] | [[Category: pseudomonas aeruginosa]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:56:35 2008'' |
Revision as of 00:56, 31 March 2008
| |||||||
| , resolution 1.10Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , , , | ||||||
| Related: | 1GZT, 1OUR, 1OUS, 1OUX, 1OVP, 1OVS, 1OXC, 1UZV, 1W43, 1W8F, 1W8H, 2BOJ, 2BP6
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
LECTIN PA-IIL OF P.AERUGINOSA COMPLEXED WITH DISACCHARIDE DERIVATIVE
Overview
Pseudomonas aeruginosa is an opportunistic bacterium showing increasing resistance to antibiotics and consequently represents elevated threatening problems in hospital environments, particularly for cystic fibrosis patients. The use of glycomimetics as an anti-adhesive strategy against microorganisms may complement the use of antibiotics. PA-IIL lectin (LecB) from P. aeruginosa constitutes an appealing target for antibacterial agents, as it has been proposed to play a key role in binding to airway epithelia and/or to be involved in biofilm formation. The lectin has an unusually high affinity for L-fucose and related oligosaccharides. In the work presented herein, the disaccharide alphaFuc1-4GlcNAc is used as a scaffold toward the synthesis of a series of glycomimetic derivatives. Microcalorimetry and structural studies indicate that several of the derivatives are potent inhibitors of the lectin, with affinity in the same range as the best known natural ligand, Lewis a, and could represent interesting leads for the development of future antibacterial compounds.
About this Structure
2JDK is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives., Marotte K, Sabin C, Preville C, Moume-Pymbock M, Wimmerova M, Mitchell EP, Imberty A, Roy R, ChemMedChem. 2007 Sep 10;2(9):1328-1338. PMID:17623286
Page seeded by OCA on Mon Mar 31 03:56:35 2008
