This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5aeq
From Proteopedia
(Difference between revisions)
m (Protected "5aeq" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | ''' | + | ==Neuronal calcium sensor (NCS-1)from Rattus norvegicus== |
| - | + | <StructureSection load='5aeq' size='340' side='right' caption='[[5aeq]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5aeq]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2yov 2yov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AEQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5aer|5aer]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aeq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5aeq RCSB], [http://www.ebi.ac.uk/pdbsum/5aeq PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Burgoyne, R]] | ||
| + | [[Category: Derrick, J P]] | ||
[[Category: Karuppiah, V]] | [[Category: Karuppiah, V]] | ||
| + | [[Category: Lian, L Y]] | ||
[[Category: Pandalaneni, S]] | [[Category: Pandalaneni, S]] | ||
| - | [[Category: Lian, L.Y]] | ||
[[Category: Saleem, M]] | [[Category: Saleem, M]] | ||
| - | [[Category: | + | [[Category: Calcium sensor]] |
| - | [[Category: | + | [[Category: Signaling protein]] |
Revision as of 12:53, 18 February 2015
Neuronal calcium sensor (NCS-1)from Rattus norvegicus
| |||||||||||
