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2e4y
From Proteopedia
(Difference between revisions)
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<StructureSection load='2e4y' size='340' side='right' caption='[[2e4y]], [[Resolution|resolution]] 3.40Å' scene=''> | <StructureSection load='2e4y' size='340' side='right' caption='[[2e4y]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2e4y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2e4y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E4Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2E4Y FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=52A:(2R,4R)-4-AMINOPYRROLIDINE-2,4-DICARBOXYLIC+ACID'>52A</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=52A:(2R,4R)-4-AMINOPYRROLIDINE-2,4-DICARBOXYLIC+ACID'>52A</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2e4u|2e4u]], [[2e4v|2e4v]], [[2e4w|2e4w]], [[2e4x|2e4x]], [[2e4z|2e4z]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2e4u|2e4u]], [[2e4v|2e4v]], [[2e4w|2e4w]], [[2e4x|2e4x]], [[2e4z|2e4z]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e4y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2e4y RCSB], [http://www.ebi.ac.uk/pdbsum/2e4y PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e4y OCA], [http://pdbe.org/2e4y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2e4y RCSB], [http://www.ebi.ac.uk/pdbsum/2e4y PDBsum]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GRM3_RAT GRM3_RAT]] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2e4y" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Buffalo rat]] |
[[Category: Jingami, H]] | [[Category: Jingami, H]] | ||
[[Category: Morikawa, K]] | [[Category: Morikawa, K]] | ||
Revision as of 11:53, 10 September 2015
Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with 2R,4R-APDC
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