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2jmq

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|PDB= 2jmq |SIZE=350|CAPTION= <scene name='initialview01'>2jmq</scene>
|PDB= 2jmq |SIZE=350|CAPTION= <scene name='initialview01'>2jmq</scene>
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= ING4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= ING4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmq OCA], [http://www.ebi.ac.uk/pdbsum/2jmq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jmq RCSB]</span>
}}
}}
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[[Category: Padro, D.]]
[[Category: Padro, D.]]
[[Category: Palacios, A.]]
[[Category: Palacios, A.]]
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[[Category: ZN]]
 
[[Category: phd]]
[[Category: phd]]
[[Category: zn]]
[[Category: zn]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:42:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:59:25 2008''

Revision as of 00:59, 31 March 2008

Image:2jmq.jpg


PDB ID 2jmq

Drag the structure with the mouse to rotate
Ligands:
Gene: ING4 (Homo sapiens)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Plant Homeodomain Finger of the tumour suppressor ING4


Overview

Plant homeodomain (PHD) fingers are frequently present in proteins involved in chromatin remodelling, and some of them bind to histones. The family of proteins inhibitors of growth (ING) contains a PHD finger that bind to histone-3 trimethylated at lysine 4, and those of ING1 and ING2 also act as nuclear phosphoinositide receptors. We have determined the structure of ING4 PHD, and characterised its binding to phosphoinositides and histone methylated tails. In contrast to ING2, ING4 is not a phosphoinositide receptor and binds with similar affinity to the different methylation states of histone-3 at lysine 4.

About this Structure

2JMQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4., Palacios A, Garcia P, Padro D, Lopez-Hernandez E, Martin I, Blanco FJ, FEBS Lett. 2006 Dec 22;580(30):6903-8. Epub 2006 Nov 30. PMID:17157298

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