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2h4c
From Proteopedia
(Difference between revisions)
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<StructureSection load='2h4c' size='340' side='right' caption='[[2h4c]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='2h4c' size='340' side='right' caption='[[2h4c]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2h4c]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2h4c]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Dabsi Dabsi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H4C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2H4C FirstGlance]. <br> |
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr> | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2h4c RCSB], [http://www.ebi.ac.uk/pdbsum/2h4c PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h4c OCA], [http://pdbe.org/2h4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2h4c RCSB], [http://www.ebi.ac.uk/pdbsum/2h4c PDBsum]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PA2AA_DABSI PA2AA_DABSI]] Heterodimer (A and B chains): phospholipase A2 that acts as a presynaptic neurotoxin and shows a PLA2 activity of 1377 umol/min/mg. In vivo, induces edema and produces neurotoxic symptoms in mice. Also exhibits indirect hemolysis, a strong myonecrotic activity and cytotoxicity. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Monomer: Snake venom phospholipase A2 (PLA2) that shows a PLA2 activity of 578 umol/min/mg. [[http://www.uniprot.org/uniprot/PA2AB_DABSI PA2AB_DABSI]] Monomer: Snake venom phospholipase A2 (PLA2) that shows a high PLA2 activity (2110 umol/min/mg). Heterodimer (A and B chains): snake venom phospholipase A2 that shows a moderate PLA2 activity (1377 umol/min/mg). Acts as a presynaptic neurotoxin. In vivo, induces edema and produces neurotoxic symptoms in mice. It exhibits indirect hemolysis and a strong myonecrotic activity and is cytotoxic. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2h4c" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Dabsi]] |
[[Category: Gopalakrishnakone, P]] | [[Category: Gopalakrishnakone, P]] | ||
[[Category: Gopalan, G]] | [[Category: Gopalan, G]] | ||
Revision as of 08:37, 10 September 2015
Structure of Daboiatoxin (heterodimeric PLA2 venom)
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