2jyd
From Proteopedia
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|PDB= 2jyd |SIZE=350|CAPTION= <scene name='initialview01'>2jyd</scene> | |PDB= 2jyd |SIZE=350|CAPTION= <scene name='initialview01'>2jyd</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jyd OCA], [http://www.ebi.ac.uk/pdbsum/2jyd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jyd RCSB]</span> | ||
}} | }} | ||
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[[Category: Matthews, J M.]] | [[Category: Matthews, J M.]] | ||
[[Category: Swanton, M K.]] | [[Category: Swanton, M K.]] | ||
| - | [[Category: ZN]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
[[Category: developmental protein]] | [[Category: developmental protein]] | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:02:32 2008'' |
Revision as of 01:02, 31 March 2008
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the fifth zinc finger of Myelin Transcription Factor 1
Overview
Zinc binding domains, or zinc fingers (ZnFs), form one of the most numerous and most diverse superclasses of protein structural motifs in eukaryotes. Although our understanding of the functions of several classes of these domains is relatively well developed, we know much less about the molecular mechanisms of action of many others. Myelin transcription factor 1 (MyT1) type ZnFs are found in organisms as diverse as nematodes and mammals and are found in a range of sequence contexts. MyT1, one of the early transcription factors expressed in the developing central nervous system, contains seven MyT1 ZnFs that are very highly conserved both within the protein and between species. We have used a range of biophysical techniques, including NMR spectroscopy and data-driven macromolecular docking, to investigate the structural basis for the interaction between MyT1 ZnFs and DNA. Our data indicate that MyT1 ZnFs recognize the major groove of DNA in a way that appears to differ from other known zinc binding domains.
About this Structure
2JYD is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1., Gamsjaeger R, Swanton MK, Kobus FJ, Lehtomaki E, Lowry JA, Kwan AH, Matthews JM, Mackay JP, J Biol Chem. 2008 Feb 22;283(8):5158-67. Epub 2007 Dec 11. PMID:18073212
Page seeded by OCA on Mon Mar 31 04:02:32 2008
Categories: Mus musculus | Single protein | Gamsjaeger, R. | Kobus, F J. | Kwan, A H. | Lehtomaki, E. | Lowry, J A. | Mackay, J P. | Matthews, J M. | Swanton, M K. | Alternative splicing | Developmental protein | Differentiation | Dna-binding | Metal binding protein | Metal-binding | Myt1 | Neurogenesis | Nucleus | Transcription | Transcription regulation | Zinc-finger
