2ki5
From Proteopedia
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|PDB= 2ki5 |SIZE=350|CAPTION= <scene name='initialview01'>2ki5</scene>, resolution 1.90Å | |PDB= 2ki5 |SIZE=350|CAPTION= <scene name='initialview01'>2ki5</scene>, resolution 1.90Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=AC2:9-HYROXYETHOXYMETHYLGUANINE'>AC2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span> |
| - | |GENE= TK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | + | |GENE= TK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10298 Human herpesvirus 1]) |
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ki5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ki5 OCA], [http://www.ebi.ac.uk/pdbsum/2ki5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ki5 RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2KI5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 2KI5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. This structure supersedes the now removed PDB entry 1KI5. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KI5 OCA]. |
==Reference== | ==Reference== | ||
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir., Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR, FEBS Lett. 1999 Jan 25;443(2):121-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9989588 9989588] | Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir., Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR, FEBS Lett. 1999 Jan 25;443(2):121-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9989588 9989588] | ||
| - | [[Category: Human herpesvirus | + | [[Category: Human herpesvirus 1]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Thymidine kinase]] | [[Category: Thymidine kinase]] | ||
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[[Category: Wien, F.]] | [[Category: Wien, F.]] | ||
[[Category: Wright, G.]] | [[Category: Wright, G.]] | ||
| - | [[Category: | + | [[Category: alphaherpesvirinae antiviral drug (aciclovir)]] |
| - | [[Category: | + | [[Category: ds-dna enveloped viruse]] |
| + | [[Category: herpesviridae]] | ||
[[Category: transferase (phosphotransferase) thymid]] | [[Category: transferase (phosphotransferase) thymid]] | ||
| - | [[Category: transferase (phosphotransferase) thymidine kinase | + | [[Category: transferase (phosphotransferase) thymidine kinase]] |
| + | [[Category: viridae]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:03:21 2008'' |
Revision as of 01:03, 31 March 2008
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| , resolution 1.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | TK (Human herpesvirus 1) | ||||||
| Activity: | Thymidine kinase, with EC number 2.7.1.21 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION
Overview
Treatment of herpes infections with nucleoside analogues requires as an initial step the activation of the compounds by thymidine kinase. As an aid to developing more effective chemotherapy, both for treatment of recurrent herpes infection and in gene therapy systems where thymidine kinase is expressed, two high-resolution X-ray structures of thymidine kinase have been compared: one with the relatively poor substrate aciclovir (Zovirax), the other with a synthetic inhibitor having an N2-substituted guanine. Both compounds have similar binding modes in spite of their size difference and apparently distinct ligand properties.
About this Structure
2KI5 is a Single protein structure of sequence from Human herpesvirus 1. This structure supersedes the now removed PDB entry 1KI5. Full crystallographic information is available from OCA.
Reference
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir., Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR, FEBS Lett. 1999 Jan 25;443(2):121-5. PMID:9989588
Page seeded by OCA on Mon Mar 31 04:03:21 2008
Categories: Human herpesvirus 1 | Single protein | Thymidine kinase | Batuwangala, T. | Bennett, M S. | Champness, J N. | Rutherford, T. | Sanderson, M R. | Summers, W C. | Sun, H. | Wien, F. | Wright, G. | Alphaherpesvirinae antiviral drug (aciclovir) | Ds-dna enveloped viruse | Herpesviridae | Transferase (phosphotransferase) thymid | Transferase (phosphotransferase) thymidine kinase | Viridae
