2nmv

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|PDB= 2nmv |SIZE=350|CAPTION= <scene name='initialview01'>2nmv</scene>, resolution 2.95&Aring;
|PDB= 2nmv |SIZE=350|CAPTION= <scene name='initialview01'>2nmv</scene>, resolution 2.95&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=NML:N-METHYLACETAMIDE'>NML</scene> and <scene name='pdbligand=FLU:2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID'>FLU</scene>
+
|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=NML:N-METHYLACETAMIDE'>NML</scene> and <scene name='pdbligand=FLU:2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID'>FLU</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= uvrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
|GENE= uvrB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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[[Category: t-fluorescein]]
[[Category: t-fluorescein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:48:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:28:00 2008''

Revision as of 13:28, 23 March 2008

Image:2nmv.gif


PDB ID 2nmv

Drag the structure with the mouse to rotate
, resolution 2.95Å
Ligands: , and
Gene: uvrB (Bacillus subtilis)
Coordinates: save as pdb, mmCIF, xml



Damage detection by the UvrABC pathway: Crystal structure of UvrB bound to fluorescein-adducted DNA


Overview

UvrB is the damage recognition element of the highly conserved UvrABC pathway that functions in the removal of bulky DNA adducts. Pivotal to this is the formation of a damage detection complex that relies on the ability of UvrB to locate and sequester diverse lesions. Whilst structures of UvrB bound to DNA have recently been reported, none address the issue of lesion recognition. Here, we describe the crystal structure of UvrB bound to a pentanucleotide containing a single fluorescein-adducted thymine that reveals a unique mechanism for damage detection entirely dependent on the exclusion of lesions larger than an undamaged nucleotide.

About this Structure

2NMV is a Protein complex structure of sequences from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Damage detection by the UvrABC pathway: crystal structure of UvrB bound to fluorescein-adducted DNA., Waters TR, Eryilmaz J, Geddes S, Barrett TE, FEBS Lett. 2006 Nov 27;580(27):6423-7. Epub 2006 Nov 3. PMID:17097086

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