This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2ktx
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
<StructureSection load='2ktx' size='340' side='right' caption='[[2ktx]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''> | <StructureSection load='2ktx' size='340' side='right' caption='[[2ktx]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ktx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2ktx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Andma Andma]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KTX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KTX FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ktx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ktx RCSB], [http://www.ebi.ac.uk/pdbsum/2ktx PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ktx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ktx OCA], [http://pdbe.org/2ktx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ktx RCSB], [http://www.ebi.ac.uk/pdbsum/2ktx PDBsum]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA]] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 23: | Line 25: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2ktx" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| Line 30: | Line 33: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Andma]] |
[[Category: Fernandez, I]] | [[Category: Fernandez, I]] | ||
[[Category: Gairi, M]] | [[Category: Gairi, M]] | ||
Revision as of 23:30, 9 September 2015
COMPLETE KALIOTOXIN FROM ANDROCTONUS MAURETANICUS MAURETANICUS, NMR, 18 STRUCTURES
| |||||||||||
