This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2wej
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
<StructureSection load='2wej' size='340' side='right' caption='[[2wej]], [[Resolution|resolution]] 1.45Å' scene=''> | <StructureSection load='2wej' size='340' side='right' caption='[[2wej]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2wej]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2wej]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WEJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WEJ FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FB2:BENZENESULFONAMIDE'>FB2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FB2:BENZENESULFONAMIDE'>FB2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1okl|1okl]], [[1i9q|1i9q]], [[1zfq|1zfq]], [[1if7|1if7]], [[1cam|1cam]], [[1t9n|1t9n]], [[1cnw|1cnw]], [[1okn|1okn]], [[1f2w|1f2w]], [[1g52|1g52]], [[2h4n|2h4n]], [[1bnm|1bnm]], [[1cnh|1cnh]], [[1bnq|1bnq]], [[1ugc|1ugc]], [[1xev|1xev]], [[1if9|1if9]], [[1ugg|1ugg]], [[1fqm|1fqm]], [[1g53|1g53]], [[1ca2|1ca2]], [[1fql|1fql]], [[1cal|1cal]], [[1i9n|1i9n]], [[1g4o|1g4o]], [[2cba|2cba]], [[1ydc|1ydc]], [[1bnv|1bnv]], [[1lzv|1lzv]], [[1ccs|1ccs]], [[1fqr|1fqr]], [[1a42|1a42]], [[1rzb|1rzb]], [[1th9|1th9]], [[1zsb|1zsb]], [[1cnb|1cnb]], [[1i8z|1i8z]], [[1hed|1hed]], [[1g48|1g48]], [[1lg5|1lg5]], [[1g0f|1g0f]], [[1bv3|1bv3]], [[1cvc|1cvc]], [[1ugd|1ugd]], [[1tg3|1tg3]], [[1yo0|1yo0]], [[1i90|1i90]], [[2wd3|2wd3]], [[1hva|1hva]], [[1fsn|1fsn]], [[1ugb|1ugb]], [[1rze|1rze]], [[1z9y|1z9y]], [[2fmz|2fmz]], [[1cnk|1cnk]], [[1bn1|1bn1]], [[1teq|1teq]], [[1rza|1rza]], [[2vvb|2vvb]], [[1ccu|1ccu]], [[1i9l|1i9l]], [[2cbc|2cbc]], [[1g46|1g46]], [[1cvb|1cvb]], [[1cao|1cao]], [[1fsq|1fsq]], [[6ca2|6ca2]], [[5ca2|5ca2]], [[1g1d|1g1d]], [[1caj|1caj]], [[2fou|2fou]], [[1cvf|1cvf]], [[1if6|1if6]], [[1bn4|1bn4]], [[1lgd|1lgd]], [[1teu|1teu]], [[1cra|1cra]], [[1ze8|1ze8]], [[1if4|1if4]], [[1hea|1hea]], [[1cah|1cah]], [[1hca|1hca]], [[1g4j|1g4j]], [[1raz|1raz]], [[1kwq|1kwq]], [[1cim|1cim]], [[1cvh|1cvh]], [[1cin|1cin]], [[1if8|1if8]], [[1i9m|1i9m]], [[1zfk|1zfk]], [[1zsa|1zsa]], [[1fqn|1fqn]], [[1lg6|1lg6]], [[1cnc|1cnc]], [[1uga|1uga]], [[1bnn|1bnn]], [[1tb0|1tb0]], [[2foq|2foq]], [[1cai|1cai]], [[2ax2|2ax2]], [[1dcb|1dcb]], [[1cnx|1cnx]], [[1ttm|1ttm]], [[2hd6|2hd6]], [[5cac|5cac]], [[4cac|4cac]], [[1cak|1cak]], [[1i9o|1i9o]], [[1cni|1cni]], [[1can|1can]], [[1yda|1yda]], [[2eu3|2eu3]], [[2wd2|2wd2]], [[1eou|1eou]], [[1yo2|1yo2]], [[1mua|1mua]], [[2ca2|2ca2]], [[1cct|1cct]], [[1oq5|1oq5]], [[2abe|2abe]], [[1ugf|1ugf]], [[1rzc|1rzc]], [[1thk|1thk]], [[2cbe|2cbe]], [[1kwr|1kwr]], [[1cay|1cay]], [[1zgf|1zgf]], [[1cng|1cng]], [[1moo|1moo]], [[2ez7|2ez7]], [[1hec|1hec]], [[1fr7|1fr7]], [[8ca2|8ca2]], [[9ca2|9ca2]], [[1zh9|1zh9]], [[1ydd|1ydd]], [[1lug|1lug]], [[1bic|1bic]], [[1caz|1caz]], [[1cvd|1cvd]], [[7ca2|7ca2]], [[1fr4|1fr4]], [[2geh|2geh]], [[1cil|1cil]], [[4ca2|4ca2]], [[1g45|1g45]], [[1ydb|1ydb]], [[1dca|1dca]], [[1fsr|1fsr]], [[2cbb|2cbb]], [[1avn|1avn]], [[12ca|12ca]], [[1i9p|1i9p]], [[1bcd|1bcd]], [[1i91|1i91]], [[1am6|1am6]], [[1cve|1cve]], [[1g3z|1g3z]], [[1heb|1heb]], [[2cbd|2cbd]], [[1zsc|1zsc]], [[1bnu|1bnu]], [[3ca2|3ca2]], [[1bnw|1bnw]], [[1zge|1zge]], [[1te3|1te3]], [[2fov|2fov]], [[1bnt|1bnt]], [[1if5|1if5]], [[1yo1|1yo1]], [[1g54|1g54]], [[1rzd|1rzd]], [[1uge|1uge]], [[1ray|1ray]], [[2fmg|2fmg]], [[1g0e|1g0e]], [[1cva|1cva]], [[1ca3|1ca3]], [[2eu2|2eu2]], [[1tg9|1tg9]], [[1tbt|1tbt]], [[1xeg|1xeg]], [[1bn3|1bn3]], [[1okm|1okm]], [[1cny|1cny]], [[1cnj|1cnj]], [[1h9n|1h9n]], [[2vva|2vva]], [[2aw1|2aw1]], [[1h4n|1h4n]], [[2fos|2fos]], [[1h9q|1h9q]], [[2weg|2weg]], [[2weh|2weh]], [[2weo|2weo]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1okl|1okl]], [[1i9q|1i9q]], [[1zfq|1zfq]], [[1if7|1if7]], [[1cam|1cam]], [[1t9n|1t9n]], [[1cnw|1cnw]], [[1okn|1okn]], [[1f2w|1f2w]], [[1g52|1g52]], [[2h4n|2h4n]], [[1bnm|1bnm]], [[1cnh|1cnh]], [[1bnq|1bnq]], [[1ugc|1ugc]], [[1xev|1xev]], [[1if9|1if9]], [[1ugg|1ugg]], [[1fqm|1fqm]], [[1g53|1g53]], [[1ca2|1ca2]], [[1fql|1fql]], [[1cal|1cal]], [[1i9n|1i9n]], [[1g4o|1g4o]], [[2cba|2cba]], [[1ydc|1ydc]], [[1bnv|1bnv]], [[1lzv|1lzv]], [[1ccs|1ccs]], [[1fqr|1fqr]], [[1a42|1a42]], [[1rzb|1rzb]], [[1th9|1th9]], [[1zsb|1zsb]], [[1cnb|1cnb]], [[1i8z|1i8z]], [[1hed|1hed]], [[1g48|1g48]], [[1lg5|1lg5]], [[1g0f|1g0f]], [[1bv3|1bv3]], [[1cvc|1cvc]], [[1ugd|1ugd]], [[1tg3|1tg3]], [[1yo0|1yo0]], [[1i90|1i90]], [[2wd3|2wd3]], [[1hva|1hva]], [[1fsn|1fsn]], [[1ugb|1ugb]], [[1rze|1rze]], [[1z9y|1z9y]], [[2fmz|2fmz]], [[1cnk|1cnk]], [[1bn1|1bn1]], [[1teq|1teq]], [[1rza|1rza]], [[2vvb|2vvb]], [[1ccu|1ccu]], [[1i9l|1i9l]], [[2cbc|2cbc]], [[1g46|1g46]], [[1cvb|1cvb]], [[1cao|1cao]], [[1fsq|1fsq]], [[6ca2|6ca2]], [[5ca2|5ca2]], [[1g1d|1g1d]], [[1caj|1caj]], [[2fou|2fou]], [[1cvf|1cvf]], [[1if6|1if6]], [[1bn4|1bn4]], [[1lgd|1lgd]], [[1teu|1teu]], [[1cra|1cra]], [[1ze8|1ze8]], [[1if4|1if4]], [[1hea|1hea]], [[1cah|1cah]], [[1hca|1hca]], [[1g4j|1g4j]], [[1raz|1raz]], [[1kwq|1kwq]], [[1cim|1cim]], [[1cvh|1cvh]], [[1cin|1cin]], [[1if8|1if8]], [[1i9m|1i9m]], [[1zfk|1zfk]], [[1zsa|1zsa]], [[1fqn|1fqn]], [[1lg6|1lg6]], [[1cnc|1cnc]], [[1uga|1uga]], [[1bnn|1bnn]], [[1tb0|1tb0]], [[2foq|2foq]], [[1cai|1cai]], [[2ax2|2ax2]], [[1dcb|1dcb]], [[1cnx|1cnx]], [[1ttm|1ttm]], [[2hd6|2hd6]], [[5cac|5cac]], [[4cac|4cac]], [[1cak|1cak]], [[1i9o|1i9o]], [[1cni|1cni]], [[1can|1can]], [[1yda|1yda]], [[2eu3|2eu3]], [[2wd2|2wd2]], [[1eou|1eou]], [[1yo2|1yo2]], [[1mua|1mua]], [[2ca2|2ca2]], [[1cct|1cct]], [[1oq5|1oq5]], [[2abe|2abe]], [[1ugf|1ugf]], [[1rzc|1rzc]], [[1thk|1thk]], [[2cbe|2cbe]], [[1kwr|1kwr]], [[1cay|1cay]], [[1zgf|1zgf]], [[1cng|1cng]], [[1moo|1moo]], [[2ez7|2ez7]], [[1hec|1hec]], [[1fr7|1fr7]], [[8ca2|8ca2]], [[9ca2|9ca2]], [[1zh9|1zh9]], [[1ydd|1ydd]], [[1lug|1lug]], [[1bic|1bic]], [[1caz|1caz]], [[1cvd|1cvd]], [[7ca2|7ca2]], [[1fr4|1fr4]], [[2geh|2geh]], [[1cil|1cil]], [[4ca2|4ca2]], [[1g45|1g45]], [[1ydb|1ydb]], [[1dca|1dca]], [[1fsr|1fsr]], [[2cbb|2cbb]], [[1avn|1avn]], [[12ca|12ca]], [[1i9p|1i9p]], [[1bcd|1bcd]], [[1i91|1i91]], [[1am6|1am6]], [[1cve|1cve]], [[1g3z|1g3z]], [[1heb|1heb]], [[2cbd|2cbd]], [[1zsc|1zsc]], [[1bnu|1bnu]], [[3ca2|3ca2]], [[1bnw|1bnw]], [[1zge|1zge]], [[1te3|1te3]], [[2fov|2fov]], [[1bnt|1bnt]], [[1if5|1if5]], [[1yo1|1yo1]], [[1g54|1g54]], [[1rzd|1rzd]], [[1uge|1uge]], [[1ray|1ray]], [[2fmg|2fmg]], [[1g0e|1g0e]], [[1cva|1cva]], [[1ca3|1ca3]], [[2eu2|2eu2]], [[1tg9|1tg9]], [[1tbt|1tbt]], [[1xeg|1xeg]], [[1bn3|1bn3]], [[1okm|1okm]], [[1cny|1cny]], [[1cnj|1cnj]], [[1h9n|1h9n]], [[2vva|2vva]], [[2aw1|2aw1]], [[1h4n|1h4n]], [[2fos|2fos]], [[1h9q|1h9q]], [[2weg|2weg]], [[2weh|2weh]], [[2weo|2weo]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wej OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wej RCSB], [http://www.ebi.ac.uk/pdbsum/2wej PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wej OCA], [http://pdbe.org/2wej PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wej RCSB], [http://www.ebi.ac.uk/pdbsum/2wej PDBsum]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| Line 20: | Line 20: | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wej ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| Line 30: | Line 30: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Carbonate dehydratase]] | [[Category: Carbonate dehydratase]] | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Alex, A]] | [[Category: Alex, A]] | ||
[[Category: Bent, A]] | [[Category: Bent, A]] | ||
Revision as of 02:30, 8 February 2016
THERMODYNAMIC OPTIMISATION OF CARBONIC ANHYDRASE FRAGMENT INHIBITORS
| |||||||||||
Categories: Carbonate dehydratase | Human | Alex, A | Bent, A | Brien, R O | Damian, L | Jones, L H | Phillips, C | Scott, A D | Disease mutation | Lyase | Metal-binding

