1gzt
From Proteopedia
(New page: 200px<br /> <applet load="1gzt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gzt, resolution 1.30Å" /> '''PSEUDOMONAS AERUGIN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GZT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with FUC and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZT OCA]]. | + | 1GZT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with FUC and CA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: FUA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GZT OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: sugar-binding protein]] | [[Category: sugar-binding protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:56:03 2007'' |
Revision as of 08:51, 30 October 2007
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PSEUDOMONAS AERUGINOSA LECTIN II (PA-IIL) TOGETHER WITH FUCOSE
Overview
Pseudomonas aeruginosa galactose- and fucose-binding lectins (PA-IL and, PA-IIL) contribute to the virulence of this pathogenic bacterium, which is, a major cause of morbidity and mortality in cystic fibrosis patients. The, crystal structure of PA-IIL in complex with fucose reveals a tetrameric, structure. Each monomer displays a nine-stranded, antiparallel b-sandwich, arrangement and contains two close calcium cations that mediate the, binding of fucose in a recognition mode unique among carbohydrate-protein, interactions. Experimental binding studies, together with theoretical, docking of fucose-containing oligosaccharides, are consistent with the, assumption that antigens of the Lewis a (Le(a)) series may be the, preferred ligands of this lectin. Precise knowledge of the ... [(full description)]
About this Structure
1GZT is a [Single protein] structure of sequence from [Pseudomonas aeruginosa] with FUC and CA as [ligands]. Structure known Active Site: FUA. Full crystallographic information is available from [OCA].
Reference
Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients., Mitchell E, Houles C, Sudakevitz D, Wimmerova M, Gautier C, Perez S, Wu AM, Gilboa-Garber N, Imberty A, Nat Struct Biol. 2002 Dec;9(12):918-21. PMID:12415289
Page seeded by OCA on Tue Oct 30 10:56:03 2007
