This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

2wg5

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Revision as of 15:19, 11 August 2016

PROTEASOME-ACTIVATING NUCLEOTIDASE (PAN) N-DOMAIN (57-134) FROM ARCHAEOGLOBUS FULGIDUS FUSED TO GCN4

Structural highlights

2wg5 is a 12 chain structure with sequence from Arcfu. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	1rb5, 1unt, 1gcm, 1llm, 2zta, 1unw, 1uo2, 1ce9, 2ccf, 1tmz, 1zil, 2ccn, 1w5l, 1rb6, 1unz, 1zij, 1w5k, 1piq, 1unx, 1uny, 1zik, 1ysa, 1w5h, 1ij2, 1unv, 1uo3, 1ij0, 2cce, 1unu, 1w5g, 1ld4, 2b22, 2b1f, 1uo0, 1uo1, 1swi, 1w5i, 2dgc, 2d3e, 1nkn, 1kql, 1gcl, 1zii, 1rb4, 1uo5, 1ihq, 1ij3, 1zta, 1uo4, 1w5j, 1ij1, 1dgc, 1rb1, 1zim, 2bni, 1gzl, 2wg6
Activity:	Proteasome ATPase, with EC number 3.6.4.8
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The proteasome forms the core of the protein quality control system in archaea and eukaryotes and also occurs in one bacterial lineage, the Actinobacteria. Access to its proteolytic compartment is controlled by AAA ATPases, whose N-terminal domains (N domains) are thought to mediate substrate recognition. The N domains of an archaeal proteasomal ATPase, Archaeoglobus fulgidus PAN, and of its actinobacterial homolog, Rhodococcus erythropolis ARC, form hexameric rings, whose subunits consist of an N-terminal coiled coil and a C-terminal OB domain. In ARC-N, the OB domains are duplicated and form separate rings. PAN-N and ARC-N can act as chaperones, preventing the aggregation of heterologous proteins in vitro, and this activity is preserved in various chimeras, even when these include coiled coils and OB domains from unrelated proteins. The structures suggest a molecular mechanism for substrate processing based on concerted radial motions of the coiled coils relative to the OB rings.

Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPases.,Djuranovic S, Hartmann MD, Habeck M, Ursinus A, Zwickl P, Martin J, Lupas AN, Zeth K Mol Cell. 2009 Jun 12;34(5):580-90. Epub 2009 May 28. PMID:19481487^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Djuranovic S, Hartmann MD, Habeck M, Ursinus A, Zwickl P, Martin J, Lupas AN, Zeth K. Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPases. Mol Cell. 2009 Jun 12;34(5):580-90. Epub 2009 May 28. PMID:19481487 doi:10.1016/j.molcel.2009.04.030

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wg5"

@@ Line 1: / Line 1: @@
 ==PROTEASOME-ACTIVATING NUCLEOTIDASE (PAN) N-DOMAIN (57-134) FROM ARCHAEOGLOBUS FULGIDUS FUSED TO GCN4==
 <StructureSection load='2wg5' size='340' side='right' caption='[[2wg5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2wg5]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WG5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2wg5]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Arcfu Arcfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WG5 FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rb5|1rb5]], [[1unt|1unt]], [[1gcm|1gcm]], [[1llm|1llm]], [[2zta|2zta]], [[1unw|1unw]], [[1uo2|1uo2]], [[1ce9|1ce9]], [[2ccf|2ccf]], [[1tmz|1tmz]], [[1zil|1zil]], [[2ccn|2ccn]], [[1w5l|1w5l]], [[1rb6|1rb6]], [[1unz|1unz]], [[1zij|1zij]], [[1w5k|1w5k]], [[1piq|1piq]], [[1unx|1unx]], [[1uny|1uny]], [[1zik|1zik]], [[1ysa|1ysa]], [[1w5h|1w5h]], [[1ij2|1ij2]], [[1unv|1unv]], [[1uo3|1uo3]], [[1ij0|1ij0]], [[2cce|2cce]], [[1unu|1unu]], [[1w5g|1w5g]], [[1ld4|1ld4]], [[2b22|2b22]], [[2b1f|2b1f]], [[1uo0|1uo0]], [[1uo1|1uo1]], [[1swi|1swi]], [[1w5i|1w5i]], [[2dgc|2dgc]], [[2d3e|2d3e]], [[1nkn|1nkn]], [[1kql|1kql]], [[1gcl|1gcl]], [[1zii|1zii]], [[1rb4|1rb4]], [[1uo5|1uo5]], [[1ihq|1ihq]], [[1ij3|1ij3]], [[1zta|1zta]], [[1uo4|1uo4]], [[1w5j|1w5j]], [[1ij1|1ij1]], [[1dgc|1dgc]], [[1rb1|1rb1]], [[1zim|1zim]], [[2bni|2bni]], [[1gzl|1gzl]], [[2wg6|2wg6]]</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_ATPase Proteasome ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.8 3.6.4.8] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wg5 RCSB], [http://www.ebi.ac.uk/pdbsum/2wg5 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wg5 OCA], [http://pdbe.org/2wg5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wg5 RCSB], [http://www.ebi.ac.uk/pdbsum/2wg5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wg5 ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 15: / Line 16: @@
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wg5 ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 25: / Line 26: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2wg5" style="background-color:#fffaf0;"></div>
 ==See Also==
@@ Line 32: / Line 34: @@
 __TOC__
 </StructureSection>
+[[Category: Arcfu]]
 [[Category: Proteasome ATPase]]
-[[Category: Saccharomyces cerevisiae]]
 [[Category: Djuranovic, S]]
 [[Category: Hartmann, M D]]

2wg5

From Proteopedia

Revision as of 15:19, 11 August 2016

PROTEASOME-ACTIVATING NUCLEOTIDASE (PAN) N-DOMAIN (57-134) FROM ARCHAEOGLOBUS FULGIDUS FUSED TO GCN4

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox