2om5
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= CNTN2, TAG1, TAX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= CNTN2, TAG1, TAX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2om5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2om5 OCA], [http://www.ebi.ac.uk/pdbsum/2om5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2om5 RCSB]</span> | ||
}} | }} | ||
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[[Category: Welte, W.]] | [[Category: Welte, W.]] | ||
[[Category: cell adhesion]] | [[Category: cell adhesion]] | ||
| - | [[Category: | + | [[Category: fibronectin]] |
| + | [[Category: ig-like c2-type]] | ||
| + | [[Category: immunoglobulin superfamily]] | ||
| + | [[Category: membrane protein]] | ||
| + | [[Category: x-ray crystallography]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:19:55 2008'' |
Revision as of 01:19, 31 March 2008
| |||||||
| , resolution 3.07Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | CNTN2, TAG1, TAX (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
N-Terminal Fragment of Human TAX1
Overview
Human TAG-1 is a neural cell adhesion molecule that is crucial for the development of the nervous system during embryogenesis. It consists of six immunoglobulin-like and four fibronectin III-like domains and is anchored to the membrane by glycosylphosphatidylinositol. Herein we present the crystal structure of the four N-terminal immunoglobulin-like domains of TAG-1 (TAG-1(Ig1-4)), known to be important in heterophilic and homophilic macromolecular interactions. The contacts of neighboring molecules within the crystal were investigated. A comparison with the structure of the chicken ortholog resulted in an alternative mode for the molecular mechanism of homophilic TAG-1 interaction. This mode of TAG-1 homophilic interaction is based on dimer formation rather than formation of a molecular zipper as proposed for the chicken ortholog.
About this Structure
2OM5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction., Mortl M, Sonderegger P, Diederichs K, Welte W, Protein Sci. 2007 Oct;16(10):2174-83. Epub 2007 Aug 31. PMID:17766378
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