This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3ao4
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase== | ==Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase== | ||
<StructureSection load='3ao4' size='340' side='right' caption='[[3ao4]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='3ao4' size='340' side='right' caption='[[3ao4]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ao4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3ao4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AO4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3AO4 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=833:3-(1,3-BENZODIOXOL-5-YL)-1-METHYL-1H-PYRAZOL-5-AMINE'>833</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=833:3-(1,3-BENZODIOXOL-5-YL)-1-METHYL-1H-PYRAZOL-5-AMINE'>833</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l3u|3l3u]], [[1bl3|1bl3]], [[3ovn|3ovn]], [[3ao1|3ao1]], [[3ao2|3ao2]], [[3ao3|3ao3]], [[3ao5|3ao5]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l3u|3l3u]], [[1bl3|1bl3]], [[3ovn|3ovn]], [[3ao1|3ao1]], [[3ao2|3ao2]], [[3ao3|3ao3]], [[3ao5|3ao5]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ao4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ao4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ao4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ao4 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ao4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ao4 OCA], [http://pdbe.org/3ao4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ao4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ao4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ao4 ProSAT]</span></td></tr> |
</table> | </table> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Chalmers, D K]] | [[Category: Chalmers, D K]] | ||
[[Category: Headey, S J]] | [[Category: Headey, S J]] | ||
Revision as of 20:31, 11 August 2016
Fragment-based approach to the design of ligands targeting a novel site on HIV-1 integrase
| |||||||||||
