4oiv

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'''Unreleased structure'''
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==Structural basis for small molecule NDB as a selective antagonist of FXR==
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<StructureSection load='4oiv' size='340' side='right' caption='[[4oiv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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The entry 4oiv is ON HOLD until Mar 20 2016
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4oiv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OIV FirstGlance]. <br>
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Authors: Xu, X., Chen, L., Hu, L., Shen, X.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XX9:N-BENZYL-N-(3-TERT-BUTYL-4-HYDROXYPHENYL)-2,6-DICHLORO-4-(DIMETHYLAMINO)BENZAMIDE'>XX9</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oiv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oiv RCSB], [http://www.ebi.ac.uk/pdbsum/4oiv PDBsum]</span></td></tr>
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Description: Structural basis for small molecule NDB as a selective antagonist of FXR
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Shen, X]]
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[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chen, L]]
[[Category: Hu, L]]
[[Category: Hu, L]]
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[[Category: Shen, X]]
[[Category: Xu, X]]
[[Category: Xu, X]]
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[[Category: Chen, L]]
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[[Category: Bile acid sensor]]
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[[Category: Nuclear]]
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[[Category: Nuclear protein receptor]]

Revision as of 14:09, 26 March 2015

Structural basis for small molecule NDB as a selective antagonist of FXR

4oiv, resolution 1.70Å

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