This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4oiv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
==Structural basis for small molecule NDB as a selective antagonist of FXR==
-
 
+
<StructureSection load='4oiv' size='340' side='right' caption='[[4oiv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
The entry 4oiv is ON HOLD until Mar 20 2016
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4oiv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OIV FirstGlance]. <br>
-
Authors: Xu, X., Chen, L., Hu, L., Shen, X.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XX9:N-BENZYL-N-(3-TERT-BUTYL-4-HYDROXYPHENYL)-2,6-DICHLORO-4-(DIMETHYLAMINO)BENZAMIDE'>XX9</scene></td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oiv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oiv RCSB], [http://www.ebi.ac.uk/pdbsum/4oiv PDBsum]</span></td></tr>
-
Description: Structural basis for small molecule NDB as a selective antagonist of FXR
+
</table>
-
[[Category: Unreleased Structures]]
+
== Function ==
-
[[Category: Shen, X]]
+
[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Chen, L]]
[[Category: Hu, L]]
[[Category: Hu, L]]
 +
[[Category: Shen, X]]
[[Category: Xu, X]]
[[Category: Xu, X]]
-
[[Category: Chen, L]]
+
[[Category: Bile acid sensor]]
 +
[[Category: Nuclear]]
 +
[[Category: Nuclear protein receptor]]

Revision as of 14:09, 26 March 2015

Structural basis for small molecule NDB as a selective antagonist of FXR

4oiv, resolution 1.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4oiv"
Personal tools