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Actinin
From Proteopedia
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{{STRUCTURE_2eyi| PDB=2eyi | SIZE=400| SCENE=Actinin/Cv/1 |right|CAPTION=Alpha-actinin-1 [[2eyi]] }} | {{STRUCTURE_2eyi| PDB=2eyi | SIZE=400| SCENE=Actinin/Cv/1 |right|CAPTION=Alpha-actinin-1 [[2eyi]] }} | ||
| - | [[Actinin]] attaches the protein actin to the Z-lines in skeletal muscle cells and to dense bodies in smooth muscle cells. Both ends of actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes | + | [[Actinin]] attaches the protein actin to the Z-lines in skeletal muscle cells and to dense bodies in smooth muscle cells. Both ends of actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes:<br /> |
| + | * '''ACTN1''' encodes α-actinin-1 (aA1) which is a cytoskeletal isoform.<br /> | ||
| + | * '''ACTN2''' encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see [[Group:MUZIC:actinin2]].<br /> | ||
| + | * '''ACTN3''' encodes aA3 which anchors actin at the muscle Z-disk.<br /> | ||
| + | * '''ACTN4''' encodes aA4 which is found in the cytoplasm and is thought to be involved in metastasis. | ||
| + | |||
| + | == Structural highlights == | ||
| + | |||
| + | Actinins contain a 3-helix bundle which is called spectrin repeat (SR). | ||
== 3D Structures of Actinin == | == 3D Structures of Actinin == | ||
Revision as of 10:37, 22 October 2015
Actinin attaches the protein actin to the Z-lines in skeletal muscle cells and to dense bodies in smooth muscle cells. Both ends of actinin contain an actin-binding domain (ABD). Actinin is encoded by different genes:
- ACTN1 encodes α-actinin-1 (aA1) which is a cytoskeletal isoform.
- ACTN2 encodes an isoform aA2 found in cardiac and skeletal muscles. For more details on ACTN2 see Group:MUZIC:actinin2.
- ACTN3 encodes aA3 which anchors actin at the muscle Z-disk.
- ACTN4 encodes aA4 which is found in the cytoplasm and is thought to be involved in metastasis.
Structural highlights
Actinins contain a 3-helix bundle which is called spectrin repeat (SR).
3D Structures of Actinin
Updated on 22-October-2015
