4rws
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target)== | |
| - | + | <StructureSection load='4rws' size='340' side='right' caption='[[4rws]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4rws]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RWS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3odu|3odu]], [[3oe6|3oe6]], [[3oe8|3oe8]], [[3oe9|3oe9]], [[3oe0|3oe0]]</td></tr> | |
| - | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rws OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rws RCSB], [http://www.ebi.ac.uk/pdbsum/4rws PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/CXCR4_HUMAN CXCR4_HUMAN]] Defects in CXCR4 are a cause of WHIM syndrome (WHIM) [MIM:[http://omim.org/entry/193670 193670]]; also known as warts, hypogammaglobulinemia, infections and myelokathexis. WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis.<ref>PMID:12692554</ref> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/CXCR4_HUMAN CXCR4_HUMAN]] Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.<ref>PMID:8329116</ref> <ref>PMID:8234909</ref> <ref>PMID:8629022</ref> <ref>PMID:8752280</ref> <ref>PMID:8752281</ref> <ref>PMID:10074102</ref> <ref>PMID:10644702</ref> <ref>PMID:10825158</ref> <ref>PMID:17197449</ref> <ref>PMID:20048153</ref> <ref>PMID:20228059</ref> <ref>PMID:20505072</ref> [[http://www.uniprot.org/uniprot/VMI2_HHV8P VMI2_HHV8P]] Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions. |
| - | [[ | + | == References == |
| - | [[ | + | <references/> |
| - | [[ | + | __TOC__ |
| - | [[ | + | </StructureSection> |
| - | [[ | + | [[Category: Lysozyme]] |
| - | [[Category: | + | |
[[Category: Abagyan, R]] | [[Category: Abagyan, R]] | ||
| - | [[Category: Qin, L]] | ||
[[Category: Cherezov, V]] | [[Category: Cherezov, V]] | ||
| + | [[Category: Fenalti, G]] | ||
| + | [[Category: GPCR, GPCR Network]] | ||
| + | [[Category: Han, G W]] | ||
| + | [[Category: Handel, T M]] | ||
| + | [[Category: Holden, L]] | ||
| + | [[Category: Kufareva, I]] | ||
| + | [[Category: Qin, L]] | ||
| + | [[Category: Stevens, R C]] | ||
| + | [[Category: Wang, C]] | ||
| + | [[Category: Wu, H]] | ||
| + | [[Category: Zheng, Y]] | ||
| + | [[Category: Cxcr4]] | ||
| + | [[Category: Gpcr]] | ||
| + | [[Category: Gpcr network]] | ||
| + | [[Category: Gpcr signaling]] | ||
| + | [[Category: Human chemokine-chemokine receptor complex]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Lipidic cubic phase]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Psi-biology]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: T4l]] | ||
| + | [[Category: Viral antagonist chemokine vmip-ii]] | ||
Revision as of 11:59, 12 February 2015
Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target)
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Categories: Lysozyme | Abagyan, R | Cherezov, V | Fenalti, G | GPCR, GPCR Network | Han, G W | Handel, T M | Holden, L | Kufareva, I | Qin, L | Stevens, R C | Wang, C | Wu, H | Zheng, Y | Cxcr4 | Gpcr | Gpcr network | Gpcr signaling | Human chemokine-chemokine receptor complex | Hydrolase | Lipidic cubic phase | Membrane | Membrane protein | Psi-biology | Signaling protein | Structural genomic | T4l | Viral antagonist chemokine vmip-ii
