4xc5
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==CRYSTAL STRUCTURE OF THE T1L REOVIRUS ATTACHMENT PROTEIN SIGMA1== |
| - | + | <StructureSection load='4xc5' size='340' side='right' caption='[[4xc5]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4xc5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s6x|3s6x]], [[1kke|1kke]], [[4gu3|4gu3]], [[4odb|4odb]], [[3eoy|3eoy]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xc5 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc5 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Reiss, K]] | [[Category: Reiss, K]] | ||
| + | [[Category: Stehle, T]] | ||
| + | [[Category: 3-sialyllactose]] | ||
| + | [[Category: Beta-barrel]] | ||
| + | [[Category: Beta-spiral repeat]] | ||
| + | [[Category: Gm2 glycan alpha-2]] | ||
| + | [[Category: Greek key motif]] | ||
| + | [[Category: Junctional adhesion molecule some]] | ||
| + | [[Category: Triple beta-spiral]] | ||
| + | [[Category: Viral attachment protein]] | ||
| + | [[Category: Viral capsid]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 13:21, 1 April 2015
CRYSTAL STRUCTURE OF THE T1L REOVIRUS ATTACHMENT PROTEIN SIGMA1
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