Adenosine kinase
From Proteopedia
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<StructureSection load='1bx4' size='350' side='right' caption='Structure of human adenosine kinase complex with adenosine (stick model), Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry [[1bx4]])' scene=''> | <StructureSection load='1bx4' size='350' side='right' caption='Structure of human adenosine kinase complex with adenosine (stick model), Mg+2 (small light green) and Cl- (large, deep green) ions (PDB entry [[1bx4]])' scene=''> | ||
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| + | == Function == | ||
| - | '''Adenosine kinase''' (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog. | + | '''Adenosine kinase''' (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog. |
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| + | == Disease == | ||
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| + | AdK deficiency causes hypermethioninemia. Overexpression of AdK in the brain leads to decrease of adenosine and is believed as the main cause of epilepsy. | ||
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</StructureSection> | </StructureSection> | ||
Revision as of 08:55, 28 October 2015
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3D structures of adenosine kinase
Updated on 28-October-2015
