Human ABO(H) Blood Group Glycosyltransferases
From Proteopedia
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We can categorize our blood types into 4 groups: A, B, AB, & O, on the surface of red blood cells, there are 2 types of antigen: A & B (each type has its own properties) If a blood cell is type A, the surface of the cell contains Antigens for type A and the body will produce antibodies for type B and vice versa for type B. Type AB contains both antigens on the surface and has neither antibodies. Blood type O has no antigens and thus have both A and B antibodies in its system. | We can categorize our blood types into 4 groups: A, B, AB, & O, on the surface of red blood cells, there are 2 types of antigen: A & B (each type has its own properties) If a blood cell is type A, the surface of the cell contains Antigens for type A and the body will produce antibodies for type B and vice versa for type B. Type AB contains both antigens on the surface and has neither antibodies. Blood type O has no antigens and thus have both A and B antibodies in its system. | ||
The A and the B antigens were found to be modified from the carbohydrate corresponding to the O blood group by the addition of different monosaccharides, the A antigen was terminated by the sugar N-acetylgalactosmine (GalNAc) while the B antigen was terminated by galactose. | The A and the B antigens were found to be modified from the carbohydrate corresponding to the O blood group by the addition of different monosaccharides, the A antigen was terminated by the sugar N-acetylgalactosmine (GalNAc) while the B antigen was terminated by galactose. | ||
| - | The human ABO(H) blood group antigens are produced by specific '''glucosyltransferase enzymes (GTs)''', the ABO blood group system is determined by what type of glucosyltransferases are expressed in the body: '''N-acetylgalactosaminyltransferase <scene name='69/691577/Gta/1'> (GTA)</scene>''' or '''Galactosyltransferase (GTB)''' | + | The human ABO(H) blood group antigens are produced by specific '''glucosyltransferase enzymes (GTs)''', the ABO blood group system is determined by what type of glucosyltransferases are expressed in the body: '''N-acetylgalactosaminyltransferase <scene name='69/691577/Gta/1'> (GTA)</scene>''' or '''Galactosyltransferase <scene name='69/691577/Gtb/1'> (GTB)</scene>''' |
Revision as of 01:33, 25 January 2015
Your Heading Here (maybe something like 'Structure')
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
