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4wkj

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wkj RCSB], [http://www.ebi.ac.uk/pdbsum/4wkj PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wkj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wkj RCSB], [http://www.ebi.ac.uk/pdbsum/4wkj PDBsum]</span></td></tr>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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RNA-DNA hybrids play essential roles in a variety of biological processes, including DNA replication, transcription, and viral integration. Ribonucleotides incorporated within DNA are hydrolyzed by RNase H enzymes in a removal process that is necessary for maintaining genomic stability. In order to understand the structural determinants involved in recognition of a hybrid substrate by RNase H we have determined the crystal structure of a dodecameric non-polypurine/polypyrimidine tract RNA-DNA duplex. A comparison to the same sequence bound to RNase H, reveals structural changes to the duplex that include widening of the major groove to 12.5 A from 4.2 A and decreasing the degree of bending along the axis which may play a crucial role in the ribonucleotide recognition and cleavage mechanism within RNase H. This structure allows a direct comparison to be made about the conformational changes induced in RNA-DNA hybrids upon binding to RNase H and may provide insight into how dysfunction in the endonuclease causes disease.
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Crystal structure of RNA-DNA duplex provides insight into conformational changes induced by RNase H binding.,Davis RR, Shaban NM, Perrino FW, Hollis T Cell Cycle. 2015 Feb 16;14(4):668-73. doi: 10.4161/15384101.2014.994996. PMID:25664393<ref>PMID:25664393</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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</StructureSection>
</StructureSection>

Revision as of 11:23, 4 March 2015

Crystallographic Structure of a Dodecameric RNA-DNA Hybrid

4wkj, resolution 2.80Å

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