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Aldose Reductase

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{{STRUCTURE_2bgq| PDB=2bgq | SIZE=400| SCENE=Aldose_Reductase/Cv/1 |right|CAPTION=Barley aldose reductase complex with sulfate [[2bgq]] }}
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<StructureSection load='1abn' size='340' side='right' caption='Human aldose reductase complex with cofactor NADP (PDB code [[1abn]])' scene=''>
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[[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway. The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR.
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== Function ==
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[[Aldose Reductase]] (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway.
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== Disease ==
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The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR.
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== Structural highlights ==
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AldR structure is of a β/α-barrel. The active site is located in the barrel core.
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</StructureSection>
== 3D Structures of Aldose Reductase ==
== 3D Structures of Aldose Reductase ==

Revision as of 07:31, 29 October 2015

Human aldose reductase complex with cofactor NADP (PDB code 1abn)

Drag the structure with the mouse to rotate

3D Structures of Aldose Reductase

Updated on 29-October-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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